… Abnormal estrogen receptor signaling may increase the risk of development of a variety of
diseases including colorectal cancer (CRC). Estrogen receptor beta (ERβ) is the predominant …

… role for estrogens has been hypothesized. Indeed, two isoforms of nuclear estrogen receptors
(ER) … While the binding of 17beta-estradiol to ERα activates anti-apoptotic pathways, the …

… estrogen receptor beta (ERβ/ESR2) demonstrates an inverse relationship with the presence
of colorectal … of colorectal adenomatous polyps and prevention of colorectal carcinoma in …

… alter the structural organization and DNA binding of estrogen receptors in a dose-dependent
manner [… For example, estradiol binding to the receptor and the affinity of the ligand-receptor …

… of target tissues, estrogen molecules diffuse into cytoplasm, and bind to estrogen receptors,
then … The estrogen receptor discovered in 1986 is named ERα, and another ER subtype …

… The estrogen receptor (ER) recognizes a molecule as estrogen based on its three-dimensional
configuration and charge, but preferentially binds E2 over E3 (2×) and E1 [3× (ref. 9)]…

… a possible therapeutic avenue in colorectal cancer, we report … Here, we aim to extend
our analysis of estrogen signaling in … estrogen pathway as a therapy in colorectal cancer (CRC). …

… Colon cancer incidence and mortality rates are lower in … that estrogen replacement therapy
(ERT) reduces cancer risk in … Estrogen replacement therapy and colorectal cancer risk in …

… Estrogen receptor β (ERβ) is a potential tumor-suppressor gene in colorectal cancer (CRC). …
and development of CRC when activated by estrogen. Further studies are needed to …

… colorectal cancer (CRC) genesis. The functionality of estrogens in cancer is mediated by the
nuclear estrogen … In this review, we discuss the roles of estrogen receptors and their multiple …