Ultrasensitive UPLCMS/MS method for analysis of etheno-DNA adducts in human white blood cells

H Li, S Cui, S Wang, X Jiang, S Zhang… - Free Radical …, 2015 - Taylor & Francis
… μg of DNA per sample [Citation19]. In this study, we report an ultrasensitive UPLC–ESI/MS/MS
For validation of the method, 34 human blood cell DNA samples randomly selected from …

[HTML][HTML] Ultrasensitive UPLC-MS-MS method for the quantitation of etheno-DNA adducts in human urine

S Cui, H Li, S Wang, X Jiang, S Zhang… - International Journal of …, 2014 - mdpi.com
Etheno-DNA adducts are generated from the metabolism of exogenous carcinogens and …
In this study, we report a new ultrasensitive UPLC-ESI-MS/MS method for the analysis of εdA …

Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS

BH Monien, F Schumacher, K Herrmann… - Analytical …, 2015 - ACS Publications
… The pellet was washed with 1 mL of cold 70% ethanol, … on the specific LC-MS/MS detection
of DNA adducts of the … , and 4-aminobiphenyl, in specimens of human pulmonary DNA. …

Etheno DNA-base adducts from endogenous reactive species

J Nair, A Barbin, I Velic, H Bartsch - Mutation Research/Fundamental and …, 1999 - Elsevier
… Promutagenic etheno (ε) adducts in DNA are generated through reactions of DNA bases …
-hydroxyalkenals, as εdA and εdC levels in WBC-DNA of female volunteers on a high ω-6 PUFA …

Increased levels of etheno-DNA adducts and genotoxicity biomarkers of long-term exposure to pure diesel engine exhaust

M Shen, P Bin, H Li, X Zhang, X Sun, H Duan… - Science of the Total …, 2016 - Elsevier
… level of etheno-DNA adducts and explore the relationship between the etheno-DNA adducts
… dissolved in 25 μL water and loaded to UPLCMS/MS for etheno-DNA adducts analysis. …

… Chromatography–Nanoelectrospray Ionization–High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral …

V Paiano, L Maertens, V Guidolin, J Yang… - Chemical research in …, 2020 - ACS Publications
… We present a validated LC-NSI-HRMS/MS method for the combined analysis of Acr-dGuo (1
and 2)… LC-NSI-HRMS-MS method for the quantitation of DNA adducts 1–4 in human oral cell …

In vivo detection of a novel endogenous ethenoDNA adduct derived from arachidonic acid and the effects of antioxidants on its formation

Y Fu, RG Nath, M Dyba, IM Cruz… - Free Radical Biology …, 2014 - Elsevier
… Detection of DHHedA in LEC rat liver and human liver DNA by the LC-MS/MS method.
Mass chromatograms from three experiments are shown. (Top) Mass chromatograms for the …

Aberrant repair of ethenoDNA adducts in leukocytes and colon tissue of colon cancer patients

T Obtułowicz, A Winczura, E Speina… - Free Radical Biology …, 2010 - Elsevier
DNA yields inter alia the exocyclic ethenoDNA adducts 1,N 6 -etheno-2′-deoxyadenosine
(εdA), 3,N 4 -etheno-… 1,N 2 -εdG in DNA of PBL of CRC patients and controls by LC/MS/MS. …

Association of etheno-DNA adduct and DNA methylation level among workers exposed to diesel engine exhaust

ML Shen, ZN He, X Zhang, HW Duan, Y Niu… - … yu Fang yi xue za zhi …, 2017 - europepmc.org
… between etheno-DNA adduct and the promoter of DNAetheno-DNA adducts were
detected using UPLC-MS/MS, including 1,N6-etheno-2'-deoxyadenosine (εdA) and 3,N4-etheno

Abundance of Four Sulfur Mustard-DNA Adducts ex Vivo and in Vivo Revealed by Simultaneous Quantification in Stable Isotope Dilution–Ultrahigh Performance …

L Yue, Y Wei, J Chen, H Shi, Q Liu… - Chemical research in …, 2014 - ACS Publications
… In this article, the reference standards of SM-DNA adducts … 2-(2-chloroethylthio)ethanol or
nontoxic chemical thiodiglycol as starting … (LC-MS/MS) provides a powerful tool for DNA adduct …