… DNA methylation, particularly in eukaryotic systems. In 1975, several groups of researchers
… a role for DNA methylation in the regulation of gene expression in eukaryotes (Riggs, 1975; …

… Understanding the factors that determine genomic methylation patterns represents a major
… that DNA methylation may have many roles in vivo, including the control of gene expression, …

… the large-genome cell manage to correctly control its own genes, which … I suggest that DNA
methylation of the vertebrate type has … effects of genome expansion in complex eukaryotes by …

… DNA METHYLATION AND DEVELOPMENT Although it is quite clear from experiments in
tissue culture that DNA methylation inhibits gene expression, it is not obvious how this …

… inside the genes (14). Furthermore, we still do not understand the mechanism by which DNA
methylation impacts gene … of heavier methylation of modestly transcribed genes than those …

… It is the very variable levels of base modifications which have made the study of DNA
methylation so frustrating and have led to the conclusion that several different functions may be …

… of de novo patterns of DNA methylatton is characterized … of DNA methylation by an essentially
unknown mechanism. In this review, some of the general concepts of DNA methylation in …

… two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can
be linked by MeCP-2.61,62 However, in some instances DNA methylation has been shown …

… strongly influence the methylation status of foetal DNA, the … regulation and gene expression
through DNA methylation and … that leads to altered DNA methylation, gene expression and a …

… of DNA methylation on gene expression are becoming common knowledge. The dynamic
changes that the DNA methylation … DNA methylation, chromatin structure and gene expression …