… taking effect through simultaneously abrogating tumor growth and fibrotic … 15 evodiamine
(EVO) derivatives as Topo I inhibitors for HCC treatment. In comparison with evodiamine, five …

… By studying its anti-tumor effects in vitro, compound 6f could … evodiamine derivatives had a
good inhibitory effect on tumor … anticancer agents for the treatment of gastrointestinal tumors. …

… approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive …
limits the anti-cancer efficacy of evodiamine, novel evodiamine derivatives with enhanced …

… Additionally, the effectiveness of these evodiamine derivatives against the tumor xenografts
demonstrated greater tolerance with no substantial loss of body weight in xenografts, in …

… (A) The effect of evodiamine derivatives on human cancer cell morphology. A549 cells
were treated with DMSO and 5 μM of compounds 10j and 18g for 48 h, and representative …

… Additionally, the research on EVO and its derivatives in liver cancer is scarce. Given this,
structure modification of EVO is of great significance to develop novel efficient anti-HCC agents. …

… its diversity of derivatives. In our continuous search for novel improved antitumor agents [24,…
, synthesis and testing of novel N13-substituted evodiamine derivatives as antitumor agents. …

… that evodiamine can inhibit the rapid proliferation of tumor cells, … angiogenesis, and act as
a potential therapeutic agent for HCC. … reactions and can be converted into active derivatives. …

… of cancer cell-lines. Furthermore, in silico target identification in combination with biological
assays confirmed that these highly active evodiamine derivatives … new anti-cancer agents …

… N14-phenyl substituted evodiamine derivatives as potential antitumor agents with favorable
… a highly active evodiamine derivative compound 6t against gastric cancer. Further anti-tumor …