… that evolutionary and ecological dynamics serve as first principles in cancer therapy and …
to the clinical application of evolutionary principles to cancer therapy. Although concerns for …

… view cancer therapy, evolution of therapy resistance … cancer therapy. Such an approach
appreciates and anticipates the ways by which all or some of the cancer cell lineages will evolve …

… We propose that evolutionary and ecological dynamics serve as first principles in cancer
therapy and that computational models can be readily constructed (computer models to guide …

… Consequently, cancer research is now at a crossroad, … apply an evolutionary ecology view
to cancer emergence and … to cancer: mathematics, ecology, cell and evolutionary biology, and …

… In order to design effective cancer therapies, we … the evolutionary ecology of host–tumour
interactions. We believe that the responses to many current and future questions about cancer …

… ecological aspects of cancer 2,3,6,25,26,27 (but see Refs 28,29,30). Hence, we focus on how
the coupling between evolution and ecology … In the context of cancer therapy, these results …

… pest control, adaptive cancer therapy allows incurable tumors … of chemo- and immune
therapies, modulated dose schedule, … by ecological and evolutionary sciences to transform cancer …

… cancer evolution: Stage I is the evolution between tumors and normal tissues, and Stage II is
the evolution … Whether cancer therapy should target such convergent phenotypes, instead of …

… of cancer with ecology and evolution have provided new insights into the initiation and spread
of cancer and new approaches to therapy. … We argue that cancers are less like invasive …

… This implies that cancers depend on interactions with the surrounding tissue. These and …
a second emphasis on cancer ecology and evolution [15], highlighting the ecology of nutrients, …