… role of Darwinian dynamics, evolutionary principles were cited in … tumor evolution during
chemotherapy emphasize resistance … If resistance arises stochastically and no resistant cells are …

… Here we review treatment strategies that explicitly incorporate evolutionary principles to limit
proliferation of resistant and prolong time to progression. Even when considered incurable, …

… Here, we review treatment strategies that explicitly incorporate evolutionary principles to
limit proliferation of resistant and prolong time to progression. Nearly all conventional cancer …

… of tumor evolution was postulated by Nowell in the 1970s. The existence of multiple phenotypes
within a single tumor was … and cancer evolution contribute to resistance to therapy and …

… In fact, because these normal cells are terminally differentiated, evolutionary principles do
not apply to their renewal, and myeloid and lymphoid cells are not only eliminated with each …

… -evolutionary dynamics of treatment-resistant cancer populations. We describe a variety of
… The initial translation of evolutionary principles into cancer therapy focused on abiraterone …

… —an evolutionary phenomenon termed “competitive release.” We present an evolution-…
limit proliferation of resistant clones by exploiting the fitness cost of the resistant phenotype. We …

… and resistance mechanisms. Here, we discuss evidence for distinct modes of tumor evolution
… -cell analysis, and circulating tumor DNA to track tumor evolution and the emergence of …

… resistance without genetic evolution. In some cases, this … evolution being broadly overlooked
as a potential resistance … to resistance is to test whether the resistance transcriptome/…

… This review begins with the discussion of the causes and principles of cancer evolution, and
… mentioned evolutionary principle of regulating gene expression to produce drug resistance. …