… Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) inhibitors (HIF-PHIs) were
… Hypoxia-inducible factor-prolyl hydroxylase domain inhibitors may also have additional …

… inhibitor design. … HIF hydroxylases and possible modes of inhibition To place studies on
the therapeutic modulation of the HIF hydroxylases (including the potential for specific inhibition) …

… how optimally chosen directed evolution techniques can be … mutants for efficient steroid
hydroxylation at the specifically targeted … variants were evolved that catalyze the hydroxylation of …

… This inhibition was initially demonstrated with dimethyloxalylglycine, a cell-… inhibitor that
reduces HIF hydroxylation 54 . A substantial number of small-molecule PHD enzyme inhibitors …

… Indeed much of our theoretical and practical understanding of directed evolution strategies
has been built on or exemplified by engineering of P450 BM3 [123-129]. While both P450 …

… hydroxylases are not yet available, computer models of the corresponding CYPs may help to
develop new inhibitors … gene (CYP11B2), which has evolved by duplication of CYP11B1 to …

… Schematic representation reflects the evolution in our thinking regarding the mechanisms
of neuroprotection by iron chelators. In the old model, deferoxamine (DFO) activates adaptive …

… enzymes and one which likely evolved as an extension of the … 25hydroxylation and 25-hydroxy-D3
1α-hydroxylation, and … -D3 24-hydroxylation and 1α,25-dihydroxy 24hydroxylation. …

… Development and evolution of animals largely rely on harness of the oxidizing potential of
… L-Mimosine has also been reported to act as a prolyl 4-hydroxylase inhibitor and has similar …

… hydroxylase (PHD) inhibitors are considered as promising solutions for stem cell-based
therapy. PHD inhibitors … , HIF-1 and especially PHD inhibitors on cell therapy. PHD structure and …