… (aromatase inhibitors) … inhibitor 4-hydroxyandrostenedione (known as formestane) pioneered
the development of a range of oral aromatase inhibitors that are either suicide inhibitors …

… levels of endogenous ATRA by inhibiting the cytochrome P450-dependent ATRA-4-hydroxylase
enzyme(s) responsible for ATRA metabolism. These inhibitors are also referred to as …

… hydroxylation activity (only ω-1, ω-2 and ω-3 products), but several of the evolved variants
catalyzed the terminal hydroxylation … and minimal product inhibition of the evolved enzyme …

… is important in order to fully elucidate the pharmacology of hydroxylase inhibitors (PHI). …
Because of the absolute reliance on a continuous supply of O 2 , animals have evolved a …

… describes known inhibitors with … evolving landscape of IDH mutant inhibitors provides
us an outlook on the discovery of novel, safer, and more effective cancer treatment strategies…

… are found in some antidepressants, in selective inhibitors of amyloid-β protein production
(for Alzheimer’s disease treatment), in farnesyl transferase inhibitors Kurasoin A and B, in …

… industrial use of oxygenases inhibition by molar substrate/… Examples are a fluorometric assay
for steroid hydroxylation [… and lack of universal directed evolution strategies. We hope that …

… Research Institute collection of vitamin D hydroxylase inhibitors singled out two structurally
related compounds, 55 and 56 (VNF), as strong inhibitors of CYP51 catalytic function (Figure …

… particular hydroxylation of the 7-position on the A ring could enhance the inhibitory potency,
whereas a methoxy group in the same position would be less favorable, and hydroxylation …

… inhibition of viral integration are being explored in numerous preclinical studies, which include
inhibition … the clinical development of HIV integrase inhibitors, the development of antiviral …