… inhibition of viral integration are being explored in numerous preclinical studies, which include
inhibition … the clinical development of HIV integrase inhibitors, the development of antiviral …

… In this paper we present for the first time a description of potent selective inhibitors of 1α-hydroxylase
and CYP24, the two key enzymes in the regulation of VD hormonal activity. Fig. 7 …

… In case of too high levels of a hormone, inhibition of its synthesis (and/or stimulation of its
breakdown) by selective inhibitors of the corresponding steroid hydroxylase has been …

… inhibitors, the diversity in the active-site chemistry and topologies found in natural MBL alleles,
and the impact of the use of antibiotics in their current evolution. We … strategies for inhibitor …

… In fact, PHD3-mediated hydroxylation has recently been … This review will examine the
evolution of oxygen sensing by the HIF … Furthermore, the use of hydroxylase inhibitors should be …

… strategies aim to deplete circulating and tissue levels of the respective mitogenic hormone by
inhibition … Selectivity to inhibition of the lyase step over the hydroxylation step is a preferred …

… Evolving strategies in the treatment of anaemia in chronic kidney disease: the HIF-prolyl
hydroxylase inhibitors. Drugs 2022;82:1565– 89. https://doi.org/10.1007/s40265-022-01783-3 …

… hydroxylase domain enzymes (PHDs) target hypoxia-inducible factor (HIF)-α subunits for
proteasomal degradation in normoxia through hydroxylation. … signaling through hydroxylation of …

… Importantly, although it has previously been shown that pharmacological PHD inhibition …
-molecule inhibition on PGD after orthotopic LT. We report for the first time that PHD inhibition is …

… number of marketed kinase inhibitors for the treatment of cancer[… to assess the consequences
of inhibiting c-Met signaling events. … Nearly a dozen small molecule inhibitors have entered …