… on inhibiting the action of angiotensin II with angiotensin-converting enzyme inhibitors or …
limited attention has been devoted to direct inhibition of the action of aldosterone. Recent …

… Recent advances have demonstrated that prolyl hydroxylase domain enzyme (PHD)
inhibitors are a promising new approach for treating CKD-induced anemia. (6) In normoxic …

… Animals require oxygen to survive, and have evolved diverse mechanisms to sense and …
4-hydroxylase inhibition. Identification of the isoform(s) of prolyl 4-hydroxylase enzymes that is …

… one is likely ribonucleotide reductase (RNR) inhibition, by preventing conversion of
ribonucleotides to deoxyribonucleotides. RNR inhibition starves the DNA polymerase from …

… However, to date, their reactions have been limited to hydroxylations and N-demethylations
via methyl group hydroxylation in animals. We define the clinically used inhibitor THP as …

… Prolyl 4-hydroxylase (PHD) enzymes are a group of dioxygenases that have evolved to sense
… Under hypoxia, inhibition of PHD activity inhibits the hydroxylation of the IKKα and IKKβ, …

… We suspect that this inhibition is due to the fact that the second molecule of … hydroxylase
to catalyse the hydroxylation of PCP is a classic example of the type of enzyme evolution in …

… 10-Hydroxyrutaecarpine (106) as the major metabolite produced by cytochrome P450-catalyzed
hydroxylation of 102, was also characterized as a selective inhibitor for human CYP1B1 …

… This Review presents a common pathway by which new enzyme activities evolve in nature
and … and co-workers proposed that Fe/αKG halogenase evolved from Fe/αKG hydroxylase. …

… hydroxylation of steroids and other substrates, the aim being to exploit the possibility of directed
evolution … to solve such classical problems as product inhibition, which is known to cause …