… exacerbation of respiratory symptoms may be particularly difficult to investigate. In fact, the
exacerbation of respiratory symptoms in patients with COPD … term exacerbation of COPD is …

… with daily records of respiratory symptoms, rescue medication use and … exacerbations are
a valid way of identifying acute symptom change in a chronic obstructive pulmonary disease …

… This could be important in exacerbations of respiratory symptoms caused by acute
inflammation of the airways and lung in patients with COPD, associated with concomitant systemic …

… We now know that COPD exacerbations are also associated with considerable physiologic
… COPD exacerbations are best defined as worsening of respiratory symptoms. However, …

… utilise respiratory symptoms and exacerbations alone to assign ABCD categories [3]. It is
recommended that symptoms and future risk of exacerbation be … management of stable COPD. …

… In this study, events of acute worsening of respiratory symptoms in the non-COPD group
were similarly defined as exacerbations in individuals with spirometrically confirmed COPD. The …

… The study concluded that COPD exacerbations exhibit two distinct patterns—sudden …
exacerbations are associated with increased peak respiratory symptoms but shorter exacerbation …

… had no return visit in 4 weeks for a respiratory problem. Failure was defined as a return
visit for persistent respiratory symptoms that required a change of an antibiotic in < 4 weeks. …

… The variety of symptoms that can worsen during an exacerbation of COPD necessitates
the use of standardized and validated instruments to evaluate the frequency, severity, and …

… symptoms of upper respiratory infection and then subdivided depending on the number
of symptoms. Other studies have defined an exacerbation as worsening of symptoms, requiring …