[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
… (for example, neutrophils and macrophages) in response to the detection of SARS-CoV-2
using endosomal … In the alveoli, SARS-CoV-2 has been shown to primarily infect alveolar type …

[HTML][HTML] The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
Optimizations of one such trait, for example the interaction between SARS-CoV-2 and …

[HTML][HTML] The proximal origin of SARS-CoV-2

KG Andersen, A Rambaut, WI Lipkin, EC Holmes… - Nature medicine, 2020 - nature.com
… For example, if SARS-CoV-2 pre-adapted in another animal species, then there is the risk
of future re-emergence events. In contrast, if the adaptive process occurred in humans, then …

[HTML][HTML] What settings have been linked to SARS-CoV-2 transmission clusters?

…, CMMID covid-19 Working Group - Wellcome open …, 2020 - ncbi.nlm.nih.gov
… Results: We found many examples of SARS-CoV-2 clusters linked to a wide range of mostly
indoor settings. Few reports came from schools, many from households, and an increasing …

[HTML][HTML] Chemistry and biology of SARS-CoV-2

A Dömling, L Gao - Chem, 2020 - cell.com
… These compounds comprise rare examples of a noncovalent SARS-CoV 3CLpro inhibitor
of moderate MW with good enzyme and antiviral inhibitory activity. However, these molecules …

[HTML][HTML] On the evolutionary epidemiology of SARS-CoV-2

T Day, S Gandon, S Lion, SP Otto - Current Biology, 2020 - cell.com
… With SARS-CoV-2, we might also expect further adaptation to its human host. For example,
although SARS-CoV-2 is already able to bind the ACE2 receptors critical for entry into human …

[HTML][HTML] Mini-review: the market growth of diagnostic and therapeutic monoclonal antibodies–SARS CoV-2 as an example

Y El Abd, A Tabll, R Smolic, M Smolic - Human antibodies, 2022 - content.iospress.com
… for both SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV)
monoclonal … Knowing the absences of efficient therapy for COVID-19 infected cases, convalescent …

[HTML][HTML] SARS-CoV-2 vaccines in development

F Krammer - Nature, 2020 - nature.com
… and many of them are in development, for example for Zika virus or cytomegalovirus. As
potential vaccines against SARS-CoV-2, promising preclinical results have been published for a …

The use of knowledge management tools in viroinformatics. Example study of a highly conserved sequence motif in Nsp3 of SARS-CoV-2 as a therapeutic target

B Robson - Computers in Biology and Medicine, 2020 - Elsevier
… to use it as the example of a substantial SARS-CoV-2 biopharmaceutical market, or even a
SARS-CoV-2 target, and the region that binds to the angiotensin converting enzyme type 2 (…

[HTML][HTML] Characteristics of SARS-CoV-2 and COVID-19

B Hu, H Guo, P Zhou, ZL Shi - Nature reviews microbiology, 2021 - nature.com
… An intermediate host usually plays an important role in the outbreak of bat-derived
emerging coronaviruses; for example, palm civets for SARS-CoV and dromedary camels for …