… studies revealing phenotypic and functional heterogeneity of exhausted CD8 + T … exhausted
PD-1 + CD8 + T-cell population is not uniform and can be divided into PD-1 lo and PD-1 …

… These data demonstrate the stability of the exhausted PD-1 hi CD39 + CD4 Tconv
phenotype and suggest that this subset encompasses tumor Ag–specific CD4 T cells. Ex vivo …

… a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia
(AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8 + …

… local antiviral T-cell phenotype. Further, we show that blockade of the PD-1/PD-L1 interaction
increases the proliferative capacity of the phenotypically exhausted HCV-specific T cells. …

… We found that for both memory and exhausted phenotypes, persistent clones had a
significantly higher TCF7 + signature pre-treatment compared to clones that contracted (Fig. 3f). …

… We propose that tumor-infiltrating skewed T cell clonotypes with an exhausted phenotype
directly attack tumor cells and that PD-1 blockade can promote infiltration of such T ex …

… patients with early excellent response to anti-PD1 therapy. In summary, an initially exhausted
lymphocyte phenotype rapidly reverted during anti-PD1 1st-line treatment. The frequently …

… Based on previous findings of increased numbers of PD-1+ T cells with the exhaustion
phenotype in PB from AML patients [20], we further characterized the influence of the AML BM …

… PD-1 + CD8 + T cells exhibit an exhausted phenotype as defined by impairment of proliferation,
cytokine production and cytotoxicity. Meanwhile, PD-L1 is expressed in several different …

Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo
phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-…