A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease

MSS Araújo, OA Martins-Filho… - Journal of …, 2000 - academic.oup.com
benznidazole and nifurtimox in treatment of Chagas' disease, our results support the use of
combinations of benznidazole … , mainly in those cases of Chagas' disease when diagnosis is …

Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments

LF Diniz, JA Urbina, IM de Andrade… - … tropical diseases, 2013 - journals.plos.org
… of posaconazole in combination with benznidazole against Trypanosoma … combination
therapy for Chagas disease. The curative action of benznidazole/posaconazole combinations

Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease

T Assíria Fontes Martins, L de Figueiredo Diniz… - PLoS …, 2015 - journals.plos.org
benznidazole in combination with itraconazole against T. cruzi in an experimental murine
model of acute Chagas disease to support the potential clinical evaluation of such combination

Clomipramine and benznidazole act synergistically and ameliorate the outcome of experimental Chagas disease

MC García, NE Ponce, LM Sanmarco… - Antimicrobial agents …, 2016 - Am Soc Microbiol
… be a strategy to improve the pharmacotherapy of Chagas disease (14, 23, 24). … Chagas
disease, the aim of this work was to evaluate the in vitro trypanocidal activity of the combination of …

Benznidazole, itraconazole and their combination in the treatment of acute experimental chagas disease in dogs

ELA Cunha, FKV da Silva Torchelsen, LM Cunha… - Experimental …, 2019 - Elsevier
… This study evaluated the combination of BZ + ITZ, in parallel to BZ and ITZ alone, in the
treatment of CD experimental acute phase in dogs infected with the VL-10 T. cruzi strain, resistant …

Curcumin enhances the anti-Trypanosoma cruzi activity of benznidazole-based chemotherapy in acute experimental Chagas disease

RD Novaes, MVP Sartini, JPF Rodrigues… - Antimicrobial agents …, 2016 - Am Soc Microbiol
combination therapies using the molecule have never been investigated in Chagas disease
… are limited to the acute phase of experimental Chagas disease. Thus, further studies are …

Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs

ELA Cunha, FKV da Silva Torchelsen… - Experimental …, 2022 - Elsevier
… Treatment for Chagas disease has limited efficacy in the chronic phase. We evaluated
benznidazole (BZ) and itraconazole (ITZ) individually and in association in dogs 16 months after …

Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease

MS Rial, ML Scalise, EC Arrúa, MI Esteva… - … tropical diseases, 2017 - journals.plos.org
… Several authors have reported different treatments in experimental murine model using
lower doses of BNZ alone or combined with other drugs, to improve treatment efficacy and …

Combination therapy using benznidazole and aspirin during the acute phase of experimental chagas disease prevents cardiovascular dysfunction and decreases …

RS Pereira, AD Malvezi, MI Lovo-Martins… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
… a new therapeutic approach for Chagas disease (14… experimental studies on the combination
of ASA and BZ in vivo. Therefore, in this study, we evaluated the efficacy of the combination

Combination chemotherapy with suboptimal doses of benznidazole and pentoxifylline sustains partial reversion of experimental Chagas' heart disease

G Vilar-Pereira, I Resende Pereira… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
… mouse models of experimental Chagas' heart disease (6, 11… Thus, combination therapy
confronting the proposed basis … , treatment period, and toxicity of benznidazole (Bz), the main …