Early detection of emerging SARS-CoV-2 variants of interest for experimental evaluation

ZS Wallace, J Davis, AM Niewiadomska… - Frontiers in …, 2022 - frontiersin.org
… ground our confidence in early detection of variants that warrant experimental evaluation. …
’s interest for evaluation, the framework also can score and rank proteome-wide SARS-CoV-2 …

Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses

T Gupta, SK Gupta - International immunopharmacology, 2020 - Elsevier
SARS-CoV-2 vaccine may address these requirements. This review paper will discuss the
experimental … adjuvant for a vaccine against rapidly emerging SARS-CoV-2. We also discuss …

Experimental models of SARS-CoV-2 infection: possible platforms to study COVID-19 pathogenesis and potential treatments

S Pandamooz, B Jurek, CP Meinung… - Annual review of …, 2022 - annualreviews.org
coronavirus 2 (SARS-CoV-2), is a global health priority. It is thus of utmost importance to
assess possible therapeutic strategies against SARS-CoV-2 using experimentalSARS-CoV-2 …

Animal hosts and experimental models of SARS-CoV-2 infection

C Parolin, S Virtuoso, M Giovanetti, S Angeletti… - Chemotherapy, 2021 - karger.com
… hosts in SARS-CoV-2 has to be explored, and animal models for COVID-19 are needed as
well to be evaluated for countermeasures against SARS-CoV-2 infection. Experimental cells, …

SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study

K Schlottau, M Rissmann, A Graaf, J Schön… - The Lancet …, 2020 - thelancet.com
… In summary, farmed animals such as chickens and pigs were resistant against intranasal
SARS-CoV-2 inoculation under our experimental conditions. The small number as well as the …

Natural and experimental SARS-CoV-2 infection in domestic and wild animals

DA Meekins, NN Gaudreault, JA Richt - Viruses, 2021 - mdpi.com
… animal species have been subjected to experimental infection with SARS-CoV-2. In addition…
of natural SARS-CoV-2 infections in species in contact with human carriers of SARS-CoV-2. …

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

S Xia, Q Lan, Y Zhu, C Wang, W Xu, Y Li… - … and Targeted Therapy, 2021 - nature.com
… We herein conducted a series of animal experiments to evaluate the systemic preclinical
safety of EK1 peptide. First, we performed an in vivo toxicity test using SD rats. Given that the …

Experimental models for the study of central nervous system infection by SARS-CoV-2

I Sanclemente-Alaman, L Moreno-Jiménez… - Frontiers in …, 2020 - frontiersin.org
… Introduction: The response to the SARS-CoV-2 coronavirus … the experimental models
previously employed for the SARS-… Pathology of experimental SARS coronavirus infection in …

Experimental transmission studies of SARS-CoV-2 in fruit bats, ferrets, pigs and chickens

K Schlottau, M Rissmann, A Graaf, J Schön, J Sehl… - 2020 - papers.ssrn.com
… In summary, farmed animals like chickens and pigs were resistant against intranasal
SARS- 368 CoV-2 inoculation under our experimental conditions. This is relevant for risk …

[HTML][HTML] Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development?

J Vandeputte, P Van Damme, J Neyts, JC Audonnet… - Biologicals, 2021 - Elsevier
… no vaccine-challenge trials have been performed so far for SARS-CoV-2, which could
have shed light on the impact of vaccination on contact and airborne transmission of SARS-CoV-2. …