Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion

N Tanaka, Y Ikeda, Y Ohta, K Deguchi, F Tian, J Shang… - Brain research, 2011 - Elsevier
Nrf2 system behaves in ischemic mouse brain after tMCAO, we performed immunohistochemical
and immnofluorescent analyses on Keap1, Nrf2… a decremental expression started at 2 h …

Role of Nrf2 in protection against traumatic brain injury in mice

W Jin, H Wang, W Yan, L Zhu, Z Hu, Y Ding… - Journal of …, 2009 - liebertpub.com
… in the regulation of DSS-induced colitis and showed that Nrf2 (À/À) mice had increased
colonic expression of inflammatory cytokines in response to challenge with DSS. In addition, …

Expression and antioxidation of Nrf2/ARE pathway in traumatic brain injury

ZG Cheng, GD Zhang, PQ Shi, BS Du - Asian Pacific journal of tropical …, 2013 - Elsevier
Nrf2/ARE pathway plays an important role in endogenous anti-oxidation process in vivo[3] …
role of Nrf2/ARE pathway in TBI through establishing the brain injury model of mice with Nrf2

Enhancing expression of Nrf2-driven genes protects the blood–brain barrier after brain injury

J Zhao, AN Moore, JB Redell… - Journal of Neuroscience, 2007 - Soc Neuroscience
… were removed, and ipsilateral hemispheres were cut into 2-mm-thick sections and
incubated in 5 ml of formamide at 55C for 24 h (mouse brain slices were incubated in 1 ml of …

The transcription factor Nrf2 is a therapeutic target against brain inflammation

NG Innamorato, AI Rojo, AJ García-Yagüe… - The Journal of …, 2008 - journals.aai.org
… We found that Nrf2 knockout mice exhibited both enhanced expression of the microglia
marker F4/80 and increased number of microglia/macrophage cells, following LPS administration…

Expression of Nrf2 in neurodegenerative diseases

CP Ramsey, CA Glass, MB Montgomery… - … of Neuropathology & …, 2007 - academic.oup.com
Nrf2 localization in affected brain regions of AD, Lewy body variant of AD (LBVAD), and PD.
By immunohistochemistry, Nrf2 is expressedexpression in the nucleus. In AD and LBVAD, …

The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice

Y Hong, W Yan, S Chen, C Sun, J Zhang - Acta Pharmacologica Sinica, 2010 - nature.com
… In the present study, we found that the expression of nuclear Nrf2 is modestly upregulated
after TBI, as indicated by western blot analysis. This finding is consistent with our previous …

NRF2-regulation in brain health and disease: implication of cerebral inflammation

M Sandberg, J Patil, B D'Angelo, SG Weber… - …, 2014 - Elsevier
… occlusion (MCAO) in an NRF2/KEAP1-dependent manner (… the expression of KEAP1,
activated NRF2 nuclear translocation, NRF2–ARE binding and increased expression of the NRF2

Ferrous iron induces Nrf2 expression in mouse brain astrocytes to prevent neurotoxicity

Z Cui, Z Zhong, Y Yang, B Wang, Y Sun… - … of Biochemical and …, 2016 - Wiley Online Library
… Therefore, Nrf2 activation in astrocytes has been … on Nrf2 expression and found that it
upregulated mRNA and protein levels. Based on this, we further examined the possible role of Nrf2

Activation of Nrf2–ARE pathway in brain after traumatic brain injury

W Yan, HD Wang, ZG Hu, QF Wang, HX Yin - Neuroscience letters, 2008 - Elsevier
… Furthermore, we also localized the expression of Nrf2 and HO-1 … Nrf2–ARE pathway is
initiated in brain after TBI. Since nuclear transduction of Nrf2 is essential for the activation of Nrf2–…