Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV1 and HTLV‐2

F Rende, I Cavallari, MG Romanelli… - Leukemia Research …, 2012 - Wiley Online Library
… In contrast, HTLV-2 has not been causally linked to human malignancy, although it may …
the pathobiology of HTLV-1 and HTLV-2 through a comparison of the expression strategies and …

Molecular mechanisms of HTLV-1 infection and pathogenesis

J Yasunaga, M Matsuoka - International journal of hematology, 2011 - Springer
… that immune activation enhances Tax expression in the CD4+ T cells of HTLV-1 LTR-Tax …
and prophylaxis strategies based on the growing knowledge of HTLV-1 molecular biology. …

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control

M Yoshida - Annual review of immunology, 2001 - annualreviews.org
… isessential for gene expression and replication of HTLV-1. The … That is, retrovirus HTLV-1
and DNA tumor viruses knock out … regulator, Rex, downregulating viral gene expression (not …

Molecular mechanisms of HTLV-1 cell-to-cell transmission

C Gross, AK Thoma-Kress - Viruses, 2016 - mdpi.com
… VS requires Tax to enhance expression of adhesion proteins (ICAM-1) in an HTLV-1-infected
T-… HTLV-1 has evolved strategies to manipulate the host cell for its transmission. Not only …

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

M Mahgoub, J Yasunaga, S Iwami… - Proceedings of the …, 2018 - National Acad Sciences
… Therefore, intermittent Tax expression is a clever strategy of HTLV-1 to evade the host
immune response most of the time, but it maintains the ability to cause de novo infection under …

Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
… therefore HTLV-1 has evolved numerous strategies to tightly regulate Tax expression while
… , and the strategies used by HTLV-1 to tightly regulate Tax expression for immune evasion …

HIV-1, HTLV-1 and normal T-cell growth: transcriptional strategies and surprises

WC Green, E Böhnlein, DW Ballard - Immunology Today, 1989 - cell.com
… long terminal repeat (LTR), and consequently the expression of viral genes under its …
expression, provide one explanation for the sustained expression of IL-2Ra observed in HTLV-1

Phenotypic and functional analyses guiding combination immune checkpoint immunotherapeutic strategies in HTLV-1 infection

DM Clements, B Crumley, GM Chew, E Davis… - Frontiers in …, 2021 - frontiersin.org
… We next examined the expression of the NCR on HTLV-1 Tax 11−19 -specific CD8 T cells;
this was limited to donors with HLA-type (HLA-A * 02:01) specificity. Tax 11−19 -specific …

Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo

P Miyazato, M Matsuoka - International immunology, 2014 - academic.oup.com
… In this review, we will discuss the interplay between Foxp3 expression and HTLV-1,
focusing on important viral proteins that might help the virus to trigger the development of such …

Fine tuning of the temporal expression of HTLV-1 and HTLV-2

I Cavallari, F Rende, C Bender, MG Romanelli… - Frontiers in …, 2013 - frontiersin.org
… genomes is greatly enhanced by several gene expression strategies that include ribosomal
frameshifting (which generates a Gag-Pro-Pol polyprotein) and alternative splicing (which …