The term ‘extended‐spectrum β‐lactamase’ (ESBL), initially ‘extended‐broad‐spectrum β‐lactamase’,
was first coined for derivatives of TEM and SHV enzymes able to hydrolyse …

… Other β-lactamases were soon discovered which were … the extended-spectrum cephalosporins
(62, 373). Hence these new β-lactamases were coined extended-spectrum β-lactamases (…

The elaboration of r-lactamase-mediated resistance in bacteria has involved increased
prevalence in certain organ-isms (notably Staphylococclus aiureius in the 1940s) and spread to …

… TEM-related ,-lactamases, which consequently may contain … The pls of extendedspectrum
P-lactamases in the TEM family … the various extended-spectrum P-lactamases (56). The …

… Because the enzyme was active against the expandedspectrum b-lactam … “extendedspectrum
b-lactamases” (ESBLs). To date, there are 1130 TEM-type and 150 SHV-type b-lactamases…

… to the development of extended spectrum β lactamases (ESBLs).… production and mutation
of β lactamases in these bacteria, … β lactamases are called extended spectrum β lactamases.9 …

… by the ability to hydrolyse an oxyimino-β-lactam at a rate ≥10% of that for … β-lactamases,
by point mutations in the parent enzymes which did not possess extended-spectrum β-lactam …

… β-lactam antibiotics among gram-negative bacteria. In recent years there has been an
increased incidence and prevalence of extended-spectrum β-lactamases … -spectrum β-lactamases …

… the extended-spectrum β-lactamases, which have become endemic worldwide. ESBLs
are serine β-lactamases, … expanded spectrum β-lactam antibiotics, and inhibition by β-lactamase …

… Production of β-lactamase is the most frequent β-lactam … world of β-lactamases,
extended-spectrum β-lactamases (… significantly expand the spectrum of previous β-lactamases to …