… by an organism carrying an extended-spectrum 13lactamase gene. TEM-1 has been termed
a fully efficient enzyme (31), and the substitutions that broaden the spectrum of TEM-1, TEM-…

… and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae
… that contained ESBL genes were included. A high prevalence of ESBL genes was found in …

… Schematic representation of three main genetic structures of extended-spectrum b-lactamase
genes acquisition. (a) A Tn3 transposon harbouring the blaTEM-1 gene (its inverted …

… or ‘broad spectrum’, when both reference substrates were hydrolysed at similar rates. Among
the broad-spectrum … An allelic variant of the chromosomal gene for class A b-lactamase K2, …

… used to search for β-lactamase-encoding genes belonging to bla … The β-lactamase genes
of all ESBL-producing isolates were … bla gene coded for a SHV ESBL (SHV-12), and 33 genes …

… lactams and related drugs in combination. Furthermore, we have reported that the metallo--lactamase
gene … the integrase gene (intI3) and the aminoglycoside acetyltransferase gene […

… encoded β-lactamase gene of Kluyvera georgiana encoded an extended-spectrum β-lactamase, …
CTX-M-type β-lactamases have 40% or less identity with TEM and SHV-type ESBLs. …

… CTX-M extended-spectrum β-lactamases (ESBLs) are increasingly prevalent worldwide …
-M β-lactamase genes are mostly located on plasmids, but Toho-1-like β-lactamase genes …

… the production of extended-spectrum β-lactamases (ESBLs) [2… the co-transfer of ESBL
genes between human and animal … The extended‐spectrum β‐lactamase genes (ESBL) genes …

… Several Gram-negative species have inherent ESBL genes carried by their chromosome.
In these bacteria, the presence of a single b-lactamase gene copy, with a weak promoter, may …