Objectives Infections as a result of extended-spectrum β-lactamase-producing Enterobacterales
(ESBL-E) are considered infections with a high public health burden. In this study, we …

… evolution of an engineered enzyme with a broad substrate spectrum toward increased β-lactam
resistance to alternative β-lactam antibiotics. Directed evolution has proved to be a …

… on the detection of hydrolysis of the cefotaxime β-lactam ring revealing the production of
a broad-spectrum β-lactamase, coupled with a tube containing tazobactam that inhibits the …

Cancer patients are vulnerable to infections, including those with extended-spectrum β-lactamase-producing
Enterobacteriaceae (ESBL-PE), and most of these infections are …

… strains that are resistant to broad-spectrum cephalosporins. The Rapid ESBL NDP test (8), …
cefotaxime β-lactam ring revealing the production of a broad-spectrum β-lactamase, coupled …

… From a clinical perspective, the carbapenem-hydrolyzing class D β-lactamase subfamily …
ability to effectively target a broad spectrum of Gram-negative bacteria and a more narrow …

… Colonization and infection with extended spectrum beta-lactamase producing
Enterobacteriaceae in high-risk patients - review of the literature from a clinical perspective …

… up to 11 May 2016 using the terms ‘[(extended spectrum beta-lactamase) OR (extended
spectrum β-lactamase) OR ESBL)] AND [LTCF OR (long-term care) OR (nursing home) OR (…

… of 8-lactam antibiotics and includes the biosynthesis, fermentation, mode of inhibition and
killing of bacteria, mechanisms of enzymatic degradation, and a clinical perspective of use. …

Background Extended-spectrum β-lactamase (ESBL)-producing pathogens have been
increasingly identified in community-onset urinary tract infection (UTI). This study was conducted …