β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of …

PNA Harris, PA Tambyah, DL Paterson - The Lancet Infectious …, 2015 - thelancet.com
… The role of β-lactam-β-lactamase inhibitors (BLBLIs) are … a β-lactam is formulated with
a β-lactamase inhibitor to extend the spectrum of activity and retain the activity of the β-lactam

Spread of Extended-Spectrum β-Lactamase—Producing Klebsiella pneumoniae: Are β-Lactamase Inhibitors of Therapeutic Value?

L Piroth, H Aubé, JM Doise… - Clinical infectious …, 1998 - academic.oup.com
… while duration of b-lactamase inhibitor therapy was significantly … (odds ratio [OR] Å 1.19),
while b-lactamase inhibitor therapy … for nosocomial tended-spectrum b-lactamases (ESBLs), …

… scales: achieving the optimal beta-lactam to beta-lactamase inhibitor ratio with continuous infusion piperacillin/tazobactam against extended spectrum beta-lactamase …

PG Cojutti, MP Pai, T Tonetti, A Siniscalchi… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
… when both the fCss/MIC BP ratio of PIP was ≥4 (where MIC … 8 mg/L) and the fCss/C T ratio
of TAZ was ≥1 (where C T was the … Css PIP to Css TAZ ratios were calculated (PIP:TAZ ratio) …

β-Lactam/β-Lactam Inhibitor Combinations for the Treatment of Bacteremia Due to Extended-Spectrum β-Lactamase–Producing Escherichia coli: A Post Hoc Analysis …

…, Extended-Spectrum Beta-Lactamases … - Clinical Infectious …, 2012 - academic.oup.com
… After adjustment for confounders, no association was found between either empirical therapy
with BLBLI (adjusted hazard ratio [HR], 1.14; 95% confidence interval [CI], .29–4.40; P = .84…

… with Fluoroquinolones or with β-Lactam-β-Lactamase Inhibitor Combinations Is a Risk Factor for Isolation of Extended-Spectrum-β-Lactamase-Producing Klebsiella …

KM Wener, V Schechner, HS Gold… - Antimicrobial agents …, 2010 - Am Soc Microbiol
… in a multivariable analysis, adjusting for the propensity score, included exposure to β-lactam-β-lactamase
inhibitor combinations (odds ratio [OR], 10.17; 95% confidence interval [CI], …

… multinational, preregistered cohort study of β-lactam/β-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-β-lactamase …

B Gutiérrez-Gutiérrez, S Perez-Galera… - Antimicrobial agents …, 2016 - Am Soc Microbiol
… The main outcome variables were cure/improvement rate at day 14 and all-cause 30-day …
The adjusted odds ratio (OR) (95% confidence interval [CI]) values for cure/improvement rate

ICU acquisition rate, risk factors, and clinical significance of digestive tract colonization with extended-Spectrum Beta-lactamase–producing Enterobacteriaceae: a …

M Detsis, S Karanika, E Mylonakis - Critical care medicine, 2017 - journals.lww.com
… Carbapenems are the treatment of choice in ESBL-PE infections ( 43 ) and, at the same time,
we found that carbapenems and beta-lactams/beta-lactamase inhibitors increase the risk of …

Beta-lactam/beta-lactamase inhibitors versus carbapenem for bloodstream infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae …

MM Sfeir, G Askin, P Christos - International journal of antimicrobial agents, 2018 - Elsevier
… Subgroup analysis restricting to pooled odds ratio from random effects model of beta-lactam/beta-lactamase-inhibitors
vs. carbapenem for empiric treatment of ESBL-producing …

Clinical efficacy of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum β-lactamase-producing …

C Gudiol, C Royo-Cebrecos, C Tebé, E Abdala… - BMJ open, 2017 - bmjopen.bmj.com
… a ratio of … . Extended-Spectrum Beta-Lactamases–Red Española de Investigación en
Patología Infecciosa/Grupo de Estudio de Infección Hospitalaria Group. β-Lactam/β-lactam inhibitor

… of β-lactam/β-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum-β-lactamase-producing Enterobacteriaceae in …

C Gudiol, C Royo-Cebrecos, E Abdala… - Antimicrobial agents …, 2017 - Am Soc Microbiol
… The primary endpoint was the case fatality rate at 30 days from onset of BSI. Secondary
outcomes included the following: (i) 7-day and (ii) 14-day case fatality rates; (iii) persistent BSI; (iv…