Extracellular vesicles: opportunities and challenges for the treatment of renal diseases

TT Tang, LL Lv, HY Lan, BC Liu - Frontiers in physiology, 2019 - frontiersin.org
Extracellular vesicles (EVs) are lipid-based membrane-bound particles secreted by virtually
all types of cells under both physiological and pathological conditions. Given their unique …

The challenges and possibilities of extracellular vesicles as therapeutic vehicles

GE Melling, E Carollo, R Conlon, JC Simpson… - European Journal of …, 2019 - Elsevier
… benefit of targeting aberrant EV signalling or treating patients with natural EVs, such as those
… of EVs and the challenges faced by the field. Many of these challenges are due to a lack of …

Recent advances on extracellular vesicles in therapeutic delivery: Challenges, solutions, and opportunities

M Lu, H Xing, Z Yang, Y Sun, T Yang, X Zhao… - European Journal of …, 2017 - Elsevier
Extracellular vesicles (EVs) are intrinsic mediators of intercellular communication in our
body, allowing functional transfer of biomolecules (lipids, proteins, and nucleic acid) between …

Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for …

M Pirisinu, TC Pham, DX Zhang, TN Hong… - Seminars in Cancer …, 2022 - Elsevier
… for studies of extracellular vesicles 2018 (… Extracellular vesicle characteristics according
to the type of parental cells. The size and density refer to the average of extracellular vesicle

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic … Limitations currently
challenging the full realization of their … Indeed, the success of this treatment in vivo has led to an …

Extracellular vesicles: opportunities and challenges for the treatment of renal fibrosis

TT Tang, BC Liu - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Extracellular vesicles (EVs) are small lipid-based membrane-bound vesicles secreted by
most cells under both physiological and pathological conditions. A key function of EVs is to …

Adult stem cell-derived extracellular vesicles in cancer treatment: opportunities and challenges

V Parfejevs, K Sagini, A Buss, K Sobolevska… - Cells, 2020 - mdpi.com
… In addition to secretory proteins, SCs also release extracellular vesicles (EV) that deliver …
implications, challenges, and opportunities these EVs hold for cancer treatment and highlight …

The potential role of extracellular vesicles in COVID-19 treatment: opportunity and challenge

Y Yan, W Zhou, Y Wang, Q Guo, F Zhao… - Frontiers in Molecular …, 2021 - frontiersin.org
treatment all over the world. Amongst the numerous ways of tackling this pandemic, some
approaches using extracellular vesicles (… EVs-based strategies for the treatment of COVID-19, …

Challenges in biomaterial-based drug delivery approach for the treatment of neurodegenerative diseases: Opportunities for extracellular vesicles

A Kumar, L Zhou, K Zhi, B Raji, S Pernell… - International Journal of …, 2020 - mdpi.com
… , balancing the potential and challenges associated with the … , addressing the persistent
challenges such as targeted drug … and limitations of incorporating extracellular vesicles (EVs) …

Extracellular vesicles: translational challenges and opportunities

H Clemmens, DW Lambert - Biochemical Society Transactions, 2018 - portlandpress.com
Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures …
There remain, however, a number of challenges that must be overcome before EVs may be …