Extracellular vesicles as promising carriers in drug delivery: considerations from a cell biologist's perspective

G Pedrioli, E Piovesana, E Vacchi, C Balbi - Biology, 2021 - mdpi.com
… Good Manufacturing Practice (GMP) grade scale-up manufacturing of extracellular vesicles
are … role of extracellular vesicles as promising carriers in drug delivery, and we report five key …

[HTML][HTML] Strategies for scalable manufacturing and translation of MSC-derived extracellular vesicles

K Adlerz, D Patel, J Rowley, K Ng, T Ahsan - Stem Cell Research, 2020 - Elsevier
… , is developing a scalable, cGMP-compatible manufacturing paradigm. Therefore, the focus
manufacturing considerations such as the selection of critical raw materials, manufacturing

[HTML][HTML] Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications

O Davies, Q Rafiq - Cell and Gene Therapy Insights, 2017 - insights.bio
… of the bioprocessing and manufacturing considerations and … secretion of trophic factors and
extracellular vesicles (EVs) into … of EVs, with these secreted extracellular bodies potentially …

Manufacturing of human extracellular vesicle-based therapeutics for clinical use

M Gimona, K Pachler, S Laner-Plamberger… - International journal of …, 2017 - mdpi.com
vesicles from pro- and eukaryotic cells, such as exosomes, microparticles, microvesicles and
apoptotic bodies, represent a dynamic extracellular vesicular … that this consideration is also …

[HTML][HTML] Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

E Rohde, K Pachler, M Gimona - Cytotherapy, 2019 - Elsevier
… The newly designed ZetaView DL-NTA Dual Laser from ParticleMetrix acknowledges
these considerations and may assist manufacturers and researchers in defining their particle …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio… some advanced works on
high-yield EV manufacturing. … in English containing “extracellular vesicles” or “exosomes” in …

Practical considerations for translating mesenchymal stromal cell-derived extracellular vesicles from bench to bed

PPY Lui, YT Leung - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) … considerations for manufacturing MSC-EVs for clinical translation.
Specifically, we will discuss Good Manufacturing Practice (GMP)-compliant manufacturing

Considerations for the bioprocessing, manufacture and translation of extracellular vesicles for therapeutic applications

QA Rafiq, OG Davies - Cell and Gene Therapy Insights, 2017 - discovery.ucl.ac.uk
… in the potential and use of extracellular vesicles (EVs) for a … the extent to which these
extracellular bodies can be employed a … of the bioprocessing and manufacturing considerations

[HTML][HTML] Unveiling the Complex World of Extracellular Vesicles: Novel Characterization Techniques and Manufacturing Considerations

JJ Lai, JJ Hill, CY Huang, GC Lee, KW Mai… - Chonnam Medical …, 2024 - ncbi.nlm.nih.gov
… industrial-scale manufacturing process considerations. Expanding the … and adherence
to Good Manufacturing Practice (GMP) … Information for Studies of Extracellular Vesicles (MISEV) …

[HTML][HTML] Guidelines for clinical translation and commercialization of extracellular vesicles and exosomes based therapeutics

K Cheng, R Kalluri - Extracellular Vesicle, 2023 - Elsevier
… the recent advances in EV manufacturing, and focuses on preclinical … The standardization
of manufacturing and robust quality … This needs to be taken into consideration when using …