Secretome and extracellular vesicles as new biological therapies for knee osteoarthritis: a systematic review

D D'Arrigo, A Roffi, M Cucchiarini, M Moretti… - Journal of clinical …, 2019 - mdpi.com
extracellular vesicles (EVs) are considered a promising option to exploit mesenchymal stem
cells’ (MSCs) properties to address knee osteoarthritis (… approaches in the treatment of OA …

The application of extracellular vesicles mediated miRNAs in osteoarthritis: current knowledge and perspective

X Shang, Y Fang, W Xin, H You - Journal of Inflammation Research, 2022 - Taylor & Francis
… ’ study, effective treatment is rare for this chronic disease. Extracellular vesicles (EVs),
including exosomes, microvesicles, and apoptosis bodies, are nano-sized vesicles with a cargo …

Reversing the surface charge of MSC‐derived small extracellular vesicles by εPL‐PEG‐DSPE for enhanced osteoarthritis treatment

K Feng, X Xie, J Yuan, L Gong, Z Zhu… - … of Extracellular …, 2021 - Wiley Online Library
… Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) possess a great
therapeutical potential for osteoarthritis (OA) treatment. However, the steric and electrostatic …

Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

J Boulestreau, M Maumus, C Jorgensen… - Advanced drug delivery …, 2021 - Elsevier
… single molecules and/or packaged within extracellular vesicles (EVs), thereby contributing …
EVs (MSC-EVs) are promising treatments for OA, exerting pleiotropic functions by producing a …

Extracellular Vesicle-Mediated miR-150-3p delivery in joint homeostasis: A potential treatment for osteoarthritis?

H Wang, J Shu, C Zhang, Y Wang, R Shi, F Yang… - Cells, 2022 - mdpi.com
osteoarthritis (OA). As regulatory molecules, microRNAs (miRNAs) can be released from
secretory cells and delivered to recipient cells through extracellular vesicles … the EV-treated rats. …

Extracellular vesicles as novel approaches for the treatment of osteoarthritis: a narrative review on potential mechanisms

SS Jousheghan, MM Sajjadi, SS Jousheghan… - Journal of Molecular …, 2021 - Springer
… characteristics of EVS in the treatment of OA. Characteristics of extracellular vesicles
Despite the advantages and beneficial effects of EVs in the treatment of OA, there are still some …

[HTML][HTML] Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

OH Jeon, DR Wilson, CC Clement, S Rathod… - JCI insight, 2019 - ncbi.nlm.nih.gov
… Several miRs showed distinct profiles when we compared young mice treated with drug
with vehicle-treated controls. Levels of mouse miR-92a-3p (mmu-miR-92a-3p), -186-5p, and -…

[HTML][HTML] Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics

B Yin, J Ni, CE Witherel, M Yang, JA Burdick, C Wen… - Theranostics, 2022 - ncbi.nlm.nih.gov
… for cartilage tissue regeneration or treatment of osteoarthritis. A few major themes emerge
… to assess treatment efficacy for cartilage regeneration, followed by an osteoarthritis model …

… stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis …

K Warmink, JL Rios, S Varderidou-Minasian… - Stem cell research & …, 2023 - Springer
… Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs)
hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its …

[HTML][HTML] Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3 …

W Liu, A Liu, X Li, Z Sun, Z Sun, Y Liu, G Wang… - Bioactive Materials, 2023 - Elsevier
Osteoarthritis (OA) is the most common disabling joint disease with no effective disease
modifying drugs. Extracellular vesicles … In this study, we demonstrated that extracellular vesicles