… the loading difference of pathological proteins between MVs and EXOs of sporadic ALS
patients and CTRLs in order to understand EVs contribution in pathological proteins clearance. …

… bilayer-enclosed vesicles from eukaryotic cells will be collectively called extracellular vesicles
(EVs… and thus expose the extracellular domains of transmembrane proteins. Four different …

… The identification of EVs as carriers of pathological proteins associated with neurodegenerative
diseases provides, at the moment, indirect support for the hypothesis that they play a …

… In exosomes (gold background), the membranes are rich in tetraspanins, a tetrameric protein
complex with critical importance for the trapping of both membrane and luminal proteins. …

… In Alzheimer’s disease the vesicles can affect the brain by changing their generation and
inducing co-release of effective proteins, such Aβ and tau, from neurons and astrocytes. …

… The main pathological … proteins, such as extracellular vesicles (EVs). EVs, which are
released by almost all cell types and range in diameter from 50–2,000 nm, carry a cargo of protein, …

… For these reasons, this review will focus on the physiological role and the pathological …
cellular and molecular pathological mechanisms, among which protein aggregation and inclusion …

… , enabling significant progress in understanding pathological mechanisms. Interest toward …
carry proteins and especially pathologic seed proteins such as Aβ, α-synuclein, or tau protein (…

… We can hypothesize that cells use EV secretion as an alternative pathway to remove
aggregate-prone pathological proteins when the protein clearing system is dysfunctional, which is a …

… , or the transfer of extracellular vesicles (EVs). EVs … proteins and miRNAs have been
described to be relatively stable in biological fluids, mainly when carried by extracellular vesicles …