Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers
D Gagliardi, N Bresolin, GP Comi, S Corti - Cellular and Molecular Life …, 2021 - Springer
… Extracellular vesicles (EVs) are small reservoirs of different … As putative vehicles of misfolded
protein propagation between … or as vehicles of proteins, nucleic acids and molecular drugs. …
protein propagation between … or as vehicles of proteins, nucleic acids and molecular drugs. …
Extracellular vesicles: unique intercellular delivery vehicles
… Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …
[HTML][HTML] Engineering of extracellular vesicles as drug delivery vehicles
SM Kim, HS Kim - Stem cell investigation, 2017 - ncbi.nlm.nih.gov
… delivery vehicles for chemical drugs, genetic materials and proteins. … These extracellular
vesicles (EVs) carry proteins, RNAs and … and thus carry membrane proteins and lipids of plasma …
vesicles (EVs) carry proteins, RNAs and … and thus carry membrane proteins and lipids of plasma …
Extracellular vesicles as delivery vehicles of specific cellular cargo
B Mir, C Goettsch - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of biomolecules
locally and systemically between organs. It has been elucidated that the specific EV …
locally and systemically between organs. It has been elucidated that the specific EV …
Extracellular vesicles: delivery vehicles of myokines
E Trovato, V Di Felice, R Barone - Frontiers in physiology, 2019 - frontiersin.org
… Thanks to their ability to deliver useful molecules (such as proteins and miRNA) in both
physiological and pathological conditions, extracellular vesicles can be thought of as promising …
physiological and pathological conditions, extracellular vesicles can be thought of as promising …
The challenges and possibilities of extracellular vesicles as therapeutic vehicles
GE Melling, E Carollo, R Conlon, JC Simpson… - European Journal of …, 2019 - Elsevier
… hydrophobic drugs and protect RNA/ protein cargo from enzymatic degradation to improve a
… , protein and carbohydrate make up of parent cells; they therefore have low vehicle toxicity …
… , protein and carbohydrate make up of parent cells; they therefore have low vehicle toxicity …
Extracellular vesicles as drug delivery vehicles to the central nervous system
… Also, fluorescence EV-labelling where EV proteins are fused with recombinant proteins (GFP
or RFP) or organic fluorescent dyes (such as lipophilic DiR, PKH67, or PHH26) are also …
or RFP) or organic fluorescent dyes (such as lipophilic DiR, PKH67, or PHH26) are also …
Extracellular vesicles–vehicles that spread cancer genes
J Rak, A Guha - Bioessays, 2012 - Wiley Online Library
… of smaller intraluminal vesicles (ILV), which can be later released to the extracellular space
as exosomes 24. Studies show that this process is regulated by Rab proteins (Rab27a/b) 47, …
as exosomes 24. Studies show that this process is regulated by Rab proteins (Rab27a/b) 47, …
Circulating extracellular vesicles as biomarkers and drug delivery vehicles in cardiovascular diseases
… Extracellular vesicles (EVs) are composed of a lipid bilayer containing transmembrane
and soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles), …
and soluble proteins. Subtypes of EVs include ectosomes (microparticles/microvesicles), …
Cancer therapy based on extracellular vesicles as drug delivery vehicles
L Cabeza, G Perazzoli, M Peña, A Cepero… - Journal of controlled …, 2020 - Elsevier
… The biogenesis of microvesicles originates from the outward budding of the plasma membrane
and subsequent release of these vesicles into the extracellular space [64]. Some proteins …
and subsequent release of these vesicles into the extracellular space [64]. Some proteins …
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