Extracellular vesicles as tools and targets in therapy for diseases
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular
space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously …
space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously …
Extracellular vesicles: emerging targets for cancer therapy
P Vader, XO Breakefield, MJA Wood - Trends in molecular medicine, 2014 - cell.com
… as targets for anticancer therapy. Here, we summarise the current knowledge on the
contributions of EVs to cancer pathogenesis and discuss novel therapeutic strategies to target EVs …
contributions of EVs to cancer pathogenesis and discuss novel therapeutic strategies to target EVs …
Extracellular vesicles as biomarkers and therapeutic targets for cancer
… they collect vesicles and carefully use the proper terms for the different small vesicles (31). …
for all kinds of small vesicles secreted in the extracellular space: exosomes, microvesicles, …
for all kinds of small vesicles secreted in the extracellular space: exosomes, microvesicles, …
On the choice of the extracellular vesicles for therapeutic purposes
C Campanella, C Caruso Bavisotto, M Logozzi… - International journal of …, 2019 - mdpi.com
… therapeutic molecules within target cells. However, we do not know exactly which exosomes
may be used in therapy in … choice for the source of extracellular vesicles for therapeutic use. …
may be used in therapy in … choice for the source of extracellular vesicles for therapeutic use. …
Extracellular vesicles: biology and emerging therapeutic opportunities
S El Andaloussi, I Mäger, XO Breakefield… - Nature reviews Drug …, 2013 - nature.com
… biogenesis could result in undesirable off-target effects not only because extracellular vesicles
are important for the regulation of normal biological processes but also because many of …
are important for the regulation of normal biological processes but also because many of …
Advances in therapeutic applications of extracellular vesicles
… Although the therapeutic efficacy of these EVs was modest, without any behavioral
improvement, a reduction in the expression of the target gene REST was observed (154). Together, …
improvement, a reduction in the expression of the target gene REST was observed (154). Together, …
Extracellular vesicles in cancer metastasis: Potential as therapeutic targets and materials
A Kogure, Y Yoshioka, T Ochiya - International journal of molecular …, 2020 - mdpi.com
… the subsequent release of these vesicles into the extracellular space. They are usually …
vesicles. In this review, we use the term EVs for all types of vesicles present in the extracellular …
vesicles. In this review, we use the term EVs for all types of vesicles present in the extracellular …
Extracellular vesicle-based therapeutics: Extracellular vesicles as therapeutic targets and agents
Y Takahashi, Y Takakura - Pharmacology & Therapeutics, 2023 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles composed of a lipid bilayer.
EVs contain biological molecules, such as nucleic acids, lipids, and proteins. As these …
EVs contain biological molecules, such as nucleic acids, lipids, and proteins. As these …
Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets
G Szabo, F Momen-Heravi - Nature reviews Gastroenterology & …, 2017 - nature.com
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the
liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, …
liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, …
Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery
… targets for therapeutic application. The suitability of various membrane proteins as targets for
therapeutic … For therapeutic application, however, a protein must be expressed and purified …
therapeutic … For therapeutic application, however, a protein must be expressed and purified …
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