Quinidine in falciparum malaria

NJ White, DA Warrell, D Bunnag, S Looareesuwan… - The Lancet, 1981 - Elsevier
… The effects of parenteral administration of quinidine were not evaluated in this study but,
like quinine, it has been shown to be safe if administered slowly.’9 The greater …

Intravenous quinidine for the treatment of severe falciparum malaria: clinical and pharmacokinetic studies

RE Phillips, DA Warrell, NJ White… - … England Journal of …, 1985 - Mass Medical Soc
Quinidine gluconate is more widely available than quinine in many countries, and our … in
severe falciparum malaria. (N Engl J Med 1985; 312:1273–8.) Over 100 years ago, quinidine, a …

Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona …

A Sowunmi, LA Salako, OJ Laoye… - Transactions of the …, 1990 - academic.oup.com
falciparum malaria were enrolled in an open, randomized, phase 2, dose-finding clinical trial
of a fixed dosage combination of quinine, quinidine … in vitro against Plasmodium falciparum

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

J Achan, AO Talisuna, A Erhart, A Yeka… - Malaria journal, 2011 - Springer
Quinine and other cinchona alkaloids including quinidine, cinchonine and cinchonidine are
… with falciparum malaria by the 1980s. With increasing resistance to chloroquine, quinine

Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro

DE Kyle, AMJ Oduola, SK Martin, WK Milhous - Transactions of the Royal …, 1990 - Elsevier
… on quinine and quinidine activities was … antimalarial activities of quinolines by calcium
antagonists presents a potentially important new dimension in the treatment of falciparum malaria

Quinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria

NJ White, S Looareesuwan, DA Warrell… - The American journal of …, 1982 - Elsevier
… of quinine have been investigated in both cerebral and uncomplicated falciparum malaria. …
It is interesting that the “quinidine effect” of marked electrocardiographic DT prolongation is …

Susceptibility of Plasmodium falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation to chloroquine in Liberia.

A Björkman, M Willcox, N Marbiah… - Bulletin of the World …, 1991 - ncbi.nlm.nih.gov
falciparum first emerged in Yekepa, Liberia, in 1988 and is spreading rapidly. We therefore
studied the susceptibility to quinine and quinidinePlasmodium falciparum malaria to quinine

Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria

S Pukrittayakamee, S Wanwimolruk… - Antimicrobial agents …, 2003 - Am Soc Microbiol
… These early studies relied on an imprecise spectrophotometric assay for quinine and
quinidine (which included all fluorescent metabolites and which therefore overestimated the true …

… to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum

AP Gorka, KS Sherlach, AC de Dios… - Antimicrobial agents …, 2013 - Am Soc Microbiol
… The 9-epimers of quinine (QN) and quinidine (QD) are known to exhibit poor cytostatic
potency against P. falciparum (Karle JM, Karle IL, Gerena L, Milhous WK, Antimicrob. Agents …

The treatment of severe falciparum malaria.

W Peters, AP Hall - British Medical Journal (Clinical research ed.), 1985 - ncbi.nlm.nih.gov
Quinidine in equivalent doses should be used if quinine is not … There were 960 patients
with falciparum malaria from Africa … quinidine for the treatment of severe falciparum malaria. …