… the development of resistance by analyzing sulfadoxine-pyrimethamine treatment failure
rates predicted by an in-host dynamics model of P. falciparum malaria. The selection pressure …

… Patients with symptoms of uncomplicated falciparum malaria and confirmed disease in …
to receive sulfadoxine/pyrimethamine (25 mg/kg sulfadoxine, and 1·25 mg/kg pyrimethamine) …

… ), sulfadoxine-pyrimethamine (SP), and coadministered AQ+SP was assessed in 351 Tanzanian
children (age range, 6–59 months) with uncomplicated Plasmodium falciparum malaria. …

… combination of pyrimethamine and sulfadoxine has increasingly … falciparum malaria. Malawi
was the first African country to make this shift, in 1993, and pyrimethamine–sulfadoxine was …

Background Artemisinin-based combination regimens are widely advocated for malarial
treatment, but other effective regimens might be cheaper and more readily available. Our aim …

… falciparum malaria treated with a single oral dose of … sulfadoxine and 1.25 mg/kg of
pyrimethamine but not exceeding the maximum dose of 1 500 mg sulfadoxine/75 mg pyrimethamine. …

… Our objective was to characterize the pharmacokinetic properties of sulfadoxine-pyrimethamine
in African adults and children with acute falciparum malaria. Despite decades of …

… of sulfadoxine-pyrimethamine resistance in P falciparum and the effectiveness of
sulfadoxine-pyrimethamine IPTp for malaria-… falciparum malaria in infected humans and in …

… Drug resistance is contributing to increasing mortality from malaria … to sulfadoxine-pyrimethamine
(SP) and transmission potential, 120 subjects with uncomplicated falciparum malaria …

… . Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in
pregnant women who receive preventive treatment. Proc Natl Acad Sci USA 2009;106:9027–32.…