… Cellular proliferation and differentiation are mediated by a family of proteins called cytokines.
Our studies on the Fas ligand and Fas have indicated that apoptosis … involvement of the Fas …

… Genes for the molecules involved in Fas-mediated apoptosis were mutatedusing a gene-…
, the cells deficient inFADD were resistant to Fas-, TNFR-1-, and DR3-induced apoptosis, …

… Additional evidence of Fas involvement in the aetiology of a number of autoimmune diseases
… now been shown to sensitize cells to Fas-induced apoptosis by increasing expression of …

… that prompted us to challenge this thinking by testing the possibility that the actual death
genes involved in the AICD of hybridomas are Fas and FasL. The critical experimental finding …

… binds to Fas, which results in target cell apoptosis. A … Fasmediated apoptosis. The phenotypes
of the loss-of-function mutants of Fas and FasL indicate that this system is involved in T cell…

… are therefore not protected from CD95-mediated apoptosis even by expression of very high
… of the apoptosis pathway or which are deficient in various molecules involved in apoptosis. …

… These results imply that the Fas/Fas ligand system involved in the T cell development plays
an important role in CTL-mediated cytotoxicity. Moreover, it suggests that the killing process …

… Therefore, Fas-Fas-L-induced apoptosis is involved in many … Fas-Fas-L-induced apoptosis
in each cell type and highlight the pathology associated with apoptosis of specific vessel cells…

… Finally, we show that resistance to Fas-mediated apoptosis is critically dependent on …
apoptotic ma chinery involved in DNA fragmentation is already in place, even in Fas-resistant cell …

… cell cycle progression and apoptosis. … cell apoptosis in vitro, we have demonstrated for
the first time that the induction of granulosa cell apoptosis and follicular atresia may involve Fas …