Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

A Mansouri, LD Ridgway, AL Korapati, Q Zhang… - Journal of Biological …, 2003 - ASBMB
… of MAPK pathways correlated with CDDP-induced apoptosis. A strong sustained activation
of both pathways seemed to be a required priming step for CDDP-induced apoptosis; this …

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

SEF Tran, TH Holmström, M Ahonen… - Journal of Biological …, 2001 - ASBMB
induced through these other DRs in the same way as in Fas signaling, especially because
the apoptotic signaling pathways induced … the kinetics of apoptosis induction by Fas, TNF, or …

Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in …

A Villunger, LA O'Reilly, N Holler, J Adams… - The Journal of …, 2000 - rupress.org
… Our results demonstrate that multimerization of CD95 (Fas/APO-1) is required to induce cell
… antiapoptotic effect by activating the p38 MAPK pathway, we analyzed lysates from sorted …

Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation: resistance to Fas ligand-induced apoptosis

W Wang, CZ Prince, Y Mou, MJ Pollman - Journal of Biological Chemistry, 2002 - ASBMB
induced ERK/MAPK activation in regulating c-FLIP expression in VSMC, we examined the
effect of inhibiting ERK/MAPK pathway activation on the Notch3-induced … ERK/MAPK pathway

Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

H Le-Niculescu, E Bonfoco, Y Kasuya… - … and cellular biology, 1999 - Taylor & Francis
… 88), the biological functions of MAPK cascades are becoming clear, … MAPK cascades in
mammals is due to cell-type-dependent variations in their function. For example, the ERK MAPK

Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses

C Choi, EN Benveniste - Brain Research Reviews, 2004 - Elsevier
… signal transduction pathways of Fas-induced apoptotic signals and … pathways such as
MAPK pathways and NF-κB may confer resistance of cells to Fas-mediated cell death and/or Fas-…

Fas and Fas-ligand expression in human pancreatic cancer

M Kornmann, T Ishiwata, J Kleeff, HG Beger… - Annals of …, 2000 - journals.lww.com
… the activation of the JNK/p38 MAPK pathway in these cells. … potential of the Fas–FasL
system to induce apoptosis in four … that p38 MAPK and JNK were activated in the Fas-responsive …

Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis

PC Singhal, M Bhaskaran, J Patel, K Patel… - The Journal of …, 2002 - journals.aai.org
… In this study, we examined the role of P38 MAPK phosphorylation in morphine-induced
as Fas and Fas ligand (FasL). We have also made an attempt to delineate other pathways by …

Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38α mitogen-activated protein kinase pathway during ischemia-reperfusion …

X Zhang, P Shan, J Alam, RJ Davis, RA Flavell… - Journal of Biological …, 2003 - ASBMB
pathways and the specific p38 MAPK isoform modulated by CO. We show that CO inhibits
Fas/Fas ligand (… Fas – / – mice do not exhibit IR-induced lung apoptosis, suggesting that the …

Fas ligand-induced apoptosis

S Nagata - Annual review of genetics, 1999 - annualreviews.org
… are resistant to Fas-induced apoptosis, but not to anticancer drug–induced apoptosis (79A). …
the ability to express Fas and FasL, and this pathway dominated the death pathway that is …