Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination

GT Belz, A Kallies - Current opinion in immunology, 2010 - Elsevier
… -bet and Eomes cooperate at a molecular level to promote CD8 + memory T cell generation
and maintenance [6] suggesting that these two transcription factors have overlapping roles …

Regulating functional cell fates in CD8 T cells

PA Shrikant, R Rao, Q Li, J Kesterson, C Eppolito… - Immunologic …, 2010 - Springer
… Therefore, it is increasingly evident that along with generation of robust effectors cells, it may
be essential to generate memory T cells that have the capacity to persist and guard the host …

Defining memory CD8 T cell

MD Martin, VP Badovinac - Frontiers in immunology, 2018 - frontiersin.org
… to identify tissue resident memory T cells (Trm) have shown that, unlike circulating cells, Trm
Future studies should more closely examine the innate and adaptive immune factors that …

CD8+ T-cell memory: the why, the when, and the how

SJ Turner, TJ Bennett… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
fate of activated CD8 + T cells into either effector or memoryT cells ([Tn] CD44 lo CD62L
hi ) and effector memory T cells ([… memory T cells is confounded by the inclusion of Tvm cells. …

Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

SM Kaech, EJ Wherry - Immunity, 2007 - cell.com
memory T cells is related to cell-fate decisions in the immune response, such as the generation
long-lived memory T cells. … in antiviral T cell populations gives rise to T cell subsets with …

Temporal and epigenetic control of plasticity and fate decision during CD8+ T-cell memory differentiation

L Pace - Cold Spring Harbor Perspectives in Biology, 2021 - cshperspectives.cshlp.org
… Conversely to naive T cells, the fate of memory T cells is predetermined and, as a consequence,
memory T cells can quickly respond and expand upon antigen challenge, deploying an …

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

G Galletti, G De Simone, EMC Mazza, S Puccio… - Nature …, 2020 - nature.com
… In summary, we have identified two subsets of human stem-like CD8 + memory T cell
progenitors with distinct fate commitments and lineage relationships. Although further work is …

Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells

K Sasaki, MA Moussawy, KI Abou-Daya… - Communications …, 2022 - nature.com
… In summary, these data indicate that naïve CD8 T cells contact activated memory T cells
and acquire an activated/memory phenotype via an MHC-I-dependent mechanism albeit …

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population

JJ Milner, H Nguyen, K Omilusik… - Proceedings of the …, 2020 - National Acad Sciences
… As our understanding of T cell states and fates has expanded, … We next utilized this revised
memory T cell nomenclature to … memory T cells with an emphasis on contrasting terminal-Tem …

Developmental origin governs CD8+ T cell fate decisions during infection

NL Smith, RK Patel, A Reynaldi, JK Grenier, J Wang… - Cell, 2018 - cell.com
… -populations of cells exist in the naive CD8 + T cell pool that are … These data demonstrate
that the naive CD8 + T cell pool is … effector and memory T cell subsets that arise after infection. …