… adaptive feedback response to KRAS G12C inhibition and find evidence of rapid RAS pathway
reactivation in the majority of KRAS G12C models. We observe that feedback reactivation …

… of drug resistance, and pre-clinical studies of G12C inhibitors have … inhibitors, the mechanisms
of resistance to G12C inhibitors and … and sustained inhibition of feedback reactivation [58]. …

… feedback resistance was evaluated in KRAS G12C inhibited … of the critical resistance
mechanisms KRAS G12C inhibitors. In … of initial response in KRAS G12C mutant lung cancer cells, …

… inhibitors, the emergence of resistant mechanisms. The biology behind KRAS G12C inhibitor
resistance … Under pressure from KRAS G12C inhibitors, a feedback loop can stimulate RTKs…

… Since our data suggest that bypass signaling occurring through WT RAS can be a key
mediator of adaptive resistance to both KRAS G12C GDP- or GTP-state inhibitors, we sought to …

… that distinguish KRAS G12C inhibitor sensitive and resistant cell lines, … 10 KRAS G12C–mutant
NSCLC cell lines to a KRAS G12C … Collectively, SHP2 inhibition led to abrogate feedback …

… Responses with first-generation KRAS G12C inhibitors have … cancer, despite intrinsic treatment
resistance mediated by molecular … inhibition overcomes adaptive feedback resistance to …

… receptor signaling from feedback inhibition is thought to mediate adaptive resistance to
targeted … could render colorectal cancers more sensitive to this feedback release than NSCLC. …

… However, RNA sequencing of MAPK feedback pathways revealed that KRAS G12C inhibition
also elicits significant suppression of DUSP, SPRY, and PHLDA family genes, which are …

… identification of any other resistance mechanisms. Using an in … KRAS mutations that confer
resistance to KRAS G12C inhibitors. … inhibition overcomes adaptive feedback resistance to …