… adaptive feedback response to KRAS G12C inhibition and find evidence of rapid RAS pathway
reactivation in the majority of KRAS G12C models. We observe that feedback reactivation …

… Discovery of new feedback resistant enzyme variants to enhance industrial production of …
Various reports over deregulation of feedback inhibition of individual biosynthetic pathways …

… on MEK inhibitors. Then, the activation of feedback networks accompanying MEK inhibition
is … involve the simultaneous inhibition of the original and resistance pathways are highlighted …

… of specific pathway inhibitors. We will then evaluate how negative feedback modulates the
… to reduced clinical efficacy of therapeutic agents and the development of drug resistance. …

… feedback activation. Therefore, we hypothesized that … inhibition of the AR and PI3K/mTOR
pathway might lead to a synergistic inhibition of cell growth and overcome drug resistance in …

… , mutants which contain a threonine deaminase resistant to isoleucine oversynthesize that …
attest, a mutant in which a pathway was no longer sensitive to endproduct inhibition, but which …

… in pathways with alternative inhibitory feedback designs. He showed that the pathway with
control by overall feedback inhibition … values than the pathway with many alternative designs ( …

… that is inactivated in normal cells by EphA 2 -mediated negative feedback inhibition of Ras.
Furthermore, we show that inhibition of the Ras–PI3K–AKT pathway by EphA 2 is required for …

… , we asked whether MEK inhibitors increase Ras activation and cause resistance to RAF …
We asked if relief of PI3K or mTOR pathway feedback also affected inhibition of MEK …

… and of a feedbackresistant enzyme form with the feedback inhibitor, leucine… The results also
suggest that thefeedback resistance of the … Quartz cuvets (1 ml) with a light path of 1 cm were …