… the initial physiological processes of mammalian oocyte activation, which has led to safety …
of human oocyte activation and the relatively rare phenomenon of fertilization failure after ICSI…

… these oocytes, the sperm head was partially or completely decondensed (4). Many studies
have suggested that failure of oocyte activation is the principal cause of fertilization failure in …

… that may lead to oocyte activation deficiency (OAD) and subsequent fertilization failure, the
… may be involved in the failure of these techniques and their relative association with OAD. …

… We applied heterologous ICSI of human sperm into mouse oocytes (mouse oocyte activation
test, MOAT) for diagnosing sperm- or oocyte-related activation deficiencies in a group of 17 …

… fertilization rates or total fertilization failure using ICSI due to sperm-related, oocyte activation
… Reported fertilization and pregnancy rates appear to be improved after ICSI-AOA compared …

… the pathophysiology of fertilization failure, focusing both on sperm- and oocyte-related factors…
of OAD; and the effectiveness and safety of AOA treatments to overcome fertilization failure. …

… oocytes are likely to be inherently compromised, and thus, despite our best efforts, destined
for fertilization failure. … be noted that failed oocyte activation is the major cause of fertilization …

… in oocyte activation at fertilization in mammals, with a particular note to studies on human
oocytes. … of treatments that attempt to promote oocyte activation as part of human IVF treatment. …

… assisted oocyte activation (AOA) is often offered to couples dealing with fertilization failure
after … can be applied to promote oocyte activation during a subsequent ICSI cycle to overcome …

… On the basis of the studies listed in Table2 , we can conclude that failed oocyte activation
seems to be the predominant reason for fertilization failure. However, it is unclear whether the …