Gestational factors throughout fetal neurodevelopment: the serotonin link

SI Hanswijk, M Spoelder, L Shan, MMM Verheij… - International journal of …, 2020 - mdpi.com
Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal
… discuss how these gestational factors affect placental and fetal brain 5-HT levels, leading …

Maternal inflammation disrupts fetal neurodevelopment via increased placental output of serotonin to the fetal brain

N Goeden, J Velasquez, KA Arnold… - Journal of …, 2016 - Soc Neuroscience
… and is associated with increased risk of neurodevelopmental disorders in the offspring. The
… to abnormal fetal neurodevelopment remain unclear. During typical development, serotonin (…

Impact of maternal serotonin transporter genotype on placental serotonin, fetal forebrain serotonin, and neurodevelopment

CL Muller, AMJ Anacker, TD Rogers… - …, 2017 - nature.com
… molecule during neurodevelopment. … fetal forebrain (Bonnin et al, 2011). Although disruptions
in this placental 5-HT synthetic pathway appear poised to impact fetal neurodevelopment

Effects of prenatal maternal stress on serotonin and fetal development

J St-Pierre, L Laurent, S King, C Vaillancourt - Placenta, 2016 - Elsevier
… These placental alterations lead to adverse neurodevelopment … an increased risk of adverse
neurodevelopmental effect in male … This study will link PNMS from a natural disaster with the …

Links between serotonin reuptake inhibition during pregnancy and neurodevelopmental delay/spectrum disorders: a systematic review of epidemiological and …

D Healy, J Le Noury, D Mangin - … Journal of Risk & Safety in …, 2016 - content.iospress.com
… to establish whether it is linked to commonly used psychotropic … linked to psychotropic
drug use, fetal anticonvulsant syndrome (FACS), fetal valproate syndrome (FVS), and fetal

Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain

A Bonnin, P Levitt - Neuroscience, 2011 - Elsevier
… , embryonic serotonin (5-HT) has been implicated in the regulation of neurodevelopmental
… For example, we recently showed that a subset of 5-HT1-receptors expressed in the fetal

Fetal serotonin signaling: setting pathways for early childhood development and behavior

TF Oberlander - Journal of Adolescent Health, 2012 - Elsevier
Finely tuning levels of the key neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) …
This article reviews the developmental consequences of two key influences that alter fetal 5-HT …

The relationship between the placental serotonin pathway and fetal growth restriction

S Ranzil, DW Walker, AJ Borg, EM Wallace… - Biochimie, 2019 - Elsevier
… (5-HT) is synthesised in the placenta and is crucial for early fetalfetal neurodevelopmental
complications are unclear. … have also been linked to neurodevelopmental disorders such as …

The neurodevelopmental effects of serotonin: a behavioural perspective

LJ Kepser, JR Homberg - Behavioural brain research, 2015 - Elsevier
… understanding of disorders with a neurodevelopmental fundament like anxiety, depression
… Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed drugs for …

Placental serotonin signaling, pregnancy outcomes, and regulation of fetal brain development

CS Rosenfeld - Biology of reproduction, 2020 - academic.oup.com
… and humans produce high concentrations of serotonin (5-HT) … source of this neurotransmitter
for fetal brain development. … serotonin-reuptake inhibitors (SSRIs) that bind to serotonin