… FGF2 and FGF9 in FGFR1 amp lung cancer cell lines was associated … inhibitor sensitivity
in FGFR1-amplified lung tumors and if it could be used as a biomarker complementing FGFR1 …

… At the clinical level, we have shown that high FGFR1 expression … inhibitor–treated
EGFR-mutated and EGFR wild-type lung adenocarcinoma. Dual EGFR and FGFR inhibition in …

… unclear, and we found FGFR1 inhibitor AZD4547 sharply … of FGFR1 amplified lung cancer.
In addition, we found a synergistic antitumor effect between si-CCND1 and FGFR1 inhibitor …

… , we report that FGFR1 is somatically amplified in 21% of lung squamous cell carcinomas
as compared to 3.4% of lung adenocarcinomas. We validate FGFR1 as a potential therapeutic …

… of FGFR1-amplified lung cancer cells remains elusive. In this study, treatment with FGFR1
inhibitor … ALDH positive proportion in FGFR1-amplified lung cancer cells in vitro, as well as …

… of lung cancer patients exhibiting overexpression of FGFR1 mRNA and protein. FGFR1
overexpression was only weakly linked to FGFR1 … Tumours with high FGFR1 expression usually …

… To examine the effect of FGFR1 inhibition on autophagy in FGFR1-amplified NSCLC cell
lines, we treated H1581 and H520 cells with 1 μM AZD4547. As shown in Fig. 2a-d, AZD4547 …

… inhibitors of this signaling cascade, both in vitro and in xenotransplanted nude mice. Collectively
our results indicate that inhibition of FGFR1 signaling impacts on cancer cell … of FGFR1 …

… -competitive FGFR1 inhibition might be a new cancer therapeutic alternative with much lower
toxicity in vivo. However, continued research is needed to examine the underlying FGFR1-…

… the FGFR inhibitor PD173074 in a large (n = 83) panel of lung cancer cell … the FGFR1
gene in 94 squamous cell lung cancers and 94 adenocarcinomas and found one mutation (FGFR1 …