Cancer-associated fibroblasts (CAFs) are important, highly heterogeneous components of
the tumor extracellular matrix that have different origins and express a diverse set of …

… Mechanical stretching of normal fibroblasts in in vitro studies induces phenotypic changes …
and remodel TME to facilitate tumor invasion [65]. Furthermore, stretched fibroblasts produce …

… and influence other processes in the tumor microenvironment, … remodeling and the influence
of matrix remodeling on the development of an immunosuppressive tumor microenvironment…

… Depletion of αSMA + cells also remodeled the immune microenvironment, including
reduced F4/80 + monocytes as seen with SHH inhibition, as well as increased regulatory T-cell …

… chemotherapy in the collagen rich microenvironment (three-dimensional collagen gel culture)
because of increased expression of the chromatin remodeling protein high mobility group …

… extracellular matrix (ECM) remodeling; they can also interact with tumor-infiltrating immune
cells and modulate the antitumor immunological state in the tumor microenvironment (TME). …

… during the pathological remodeling of organ tissue.4-6 It … remodeling a changing
microenvironment. Adding to this … MSCs in defining fibroblasts heterogeneity is one explanation, …

… The remodeling of … Fibroblast heterogeneity can be clearly observed in various anatomic
components [131], and the different origins of CAFs result in the promotion of heterogeneous …

… fibroblasts in these tumors. αSMA, PDGFRβ and NG2 signifi‑ cantly overlap with each other
in identifying a mixed population of fibroblasts … microenvironment associated fibroblasts are a …

… Mesenchymal-derived Cav-1 also conferred microenvironment remodeling to favor the
migration of neoplastic cells. CAFs further facilitated intra- and extravasation and were shown to …