Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis
… the biological function of fibroblast subtypes in lung fibrosis, we … on lung fibrosis from both
mouse models and human diseases published recently. We defined lung fibroblast subtypes …
mouse models and human diseases published recently. We defined lung fibroblast subtypes …
Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis
KM Fries, T Blieden, RJ Looney, GD Sempowski… - Clinical immunology and …, 1994 - Elsevier
… Considering that fibroblasts play a crucial role in pulmonary fibrosis, … of fibroblast lines and
clones may help elucidate fibrotic … formation by a neonatal rat lung fibroblast subtype. J. Biol. …
clones may help elucidate fibrotic … formation by a neonatal rat lung fibroblast subtype. J. Biol. …
Heterogeneity of fibroblasts and myofibroblasts in pulmonary fibrosis
DM Habiel, CM Hogaboam - Current pathobiology reports, 2017 - Springer
… (IPF) is the most common form of interstitial lung … of fibroblasts and myofibroblasts in IPF
lungs. In this review, the origin and contribution of fibroblast and myofibroblasts in lung fibrosis …
lungs. In this review, the origin and contribution of fibroblast and myofibroblasts in lung fibrosis …
[HTML][HTML] Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms
… By functionally interrogating CAF heterogeneity using the same therapeutics received by
patients, we identify three functional subtypes: (1) robustly protective of cancers and highly …
patients, we identify three functional subtypes: (1) robustly protective of cancers and highly …
[HTML][HTML] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
… However, there is no common consensus on fibroblast subtypes, lineages, biological properties,
signaling, and plasticity, which severely hampers our understanding of the mechanisms …
signaling, and plasticity, which severely hampers our understanding of the mechanisms …
[HTML][HTML] GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
X Shi, J Wang, X Zhang, S Yang, W Luo, S Wang… - Cell & Bioscience, 2022 - Springer
… , and single-cell sequencing, spatial transcriptome sequencing and an analysis of markers
of cell subtypes were performed to identify fibroblast subtypes. A group of heterogeneous …
of cell subtypes were performed to identify fibroblast subtypes. A group of heterogeneous …
Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
DW Waters, KEC Blokland… - … of Physiology-Lung …, 2018 - journals.physiology.org
… been shown to be a feature of disease (4), and the SOCS/STAT3 silencing mechanism has
also been reported to be diminished in idiopathic pulmonary fibrosis-derived fibroblasts (83). …
also been reported to be diminished in idiopathic pulmonary fibrosis-derived fibroblasts (83). …
[HTML][HTML] Machine Learning and Single-Cell Analysis Identify Molecular Features of IPF-Associated Fibroblast Subtypes and Their Implications on IPF Prognosis
J Hou, Y Yang, X Han - International Journal of Molecular Sciences, 2023 - mdpi.com
… Herein, we conducted a thorough analysis of the fibroblast landscape in human idiopathic
pulmonary fibrosis (IPF) and successfully identified two predominant subpopulations primarily …
pulmonary fibrosis (IPF) and successfully identified two predominant subpopulations primarily …
Definition and signatures of lung fibroblast populations in development and fibrosis in mice and men
… Prospective isolation of these fibroblast subpopulations, … of fibroblast heterogeneity in
homeostasis and fibrotic … all mesenchymal subtypes may contribute to pulmonary fibrosis. …
homeostasis and fibrotic … all mesenchymal subtypes may contribute to pulmonary fibrosis. …
[HTML][HTML] Single-cell RNA sequencing reveals special basal cells and fibroblasts in idiopathic pulmonary fibrosis
C Jin, Y Chen, Y Wang, J Li, J Liang, S Zheng… - Scientific Reports, 2024 - nature.com
… In this study, we identified six fibroblast subtypes. In addition to … a close interaction among
each subtype of fibroblasts through ligand–… In summary, we identified a new fibroblast subtype …
each subtype of fibroblasts through ligand–… In summary, we identified a new fibroblast subtype …
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- idiopathic pulmonary fibrosis
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- resolution of lung fibrosis
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- single cell deconvolution mouse pulmonary fibrosis
- lung fibrosis single cell sequencing