… Many studies of HNSCC use fibroblasts isolated from ‘normal-like’ … , fibroblasts from fully
normal mucosa or fibroblast cell lines, referred in this review collectively as normal fibroblasts (…

… a key role of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs
or M2 macrophages) in the development and metastasis of head and neck squamous cell …

Simple Summary Cancer-associated fibroblasts (CAFs) are the major cellular component of
the tumor microenvironment and have been shown to stimulate tumor growth, epithelial-to-…

Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex
malignant diseases with a high level of heterogeneity and, as a result, a wide range of …

… from tumor cells, fibroblasts were differentially trypsinized from mucosa, skin and tumor,
from patients undergoing surgical resection for head and neck cancer without prior treatment. …

… fibroblast explants were established using our previously described protocol (4), and all
fibroblast … In all experiments, results presented are from fibroblasts derived from a minimum of …

… Cancer-associated fibroblasts (CAFs) have been shown to … microenvironment (TME) in
head and neck squamous cell carcinoma (… Six pairs of CAFs and normal fibroblasts (NFs) were …

… between stromal fibroblasts and cancer stem cell (CSC) biology in head and neck squamous
… conditioned media from cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) …

… Fibroblasts isolated from primary tumor tissue were defined as cancer-associated fibroblasts
(CAFs), whereas fibroblasts … margins were defined as peritumoral fibroblasts (PtFs). CAFs …

… The most striking finding in this study was the absence of other MMPs expressed in vivo by
fibroblasts. Analysis of head and neck tumors for MMPs has consistently demonstrated that …