… The field of targeted protein degradation (TPD) is a rapidly developing … targeted protein
degradation approaches and focus on the current status of clinical translation of TPD in cancer …

… hope to provide a prime for both biologists and chemists who are interested in this vibrant
field. … Treatment of complicated diseases, such as cancer, often require more than one targets. …

… Since the first PROTAC was reported in 2001 [5], the field of targeted protein degradation
by small molecules has undergone rapid development, with a main focus on the advances of …

… molecules without affecting their protein levels. An emerging … of Targeted Protein Degradation
(TPD) of cellular targets by … the field with a focus on clinical translation in cancer therapy. …

… field, the breadth of the proteins targeted by PROTACs and the biological effects of their
degradation… For instance, HER2 overexpression is found in breast and gastro-esophageal cancer…

… increase in the surface area that can be utilized to recruit the protein of interest to an E3 …
PIK3CA gene product PI3Kα is one of the most sought after mutated targets in various oncology …

… target that undergoes proteasomal degradation (Figure 1). Here, we will offer a brief introduction
to targeted protein degradation and … review of the area, please check a recent review [ …

… have been explored in targeted protein degradation to date. … for the field of targeted protein
degradation and review the major … degradation of target proteins and is essential in all cancer …

… Target-independent resistance mechanisms including compensation by other pathways is
an additional challenge for the field of molecular cancer … MOA, targeted protein degradation (…

… degradation results. In this paper, we classify PROTACs according to E3 ligase and summarize
the PROTAC degradation strategies for different target proteins (… knowledge in this area. …