… The mannose-binding pocket of FimH is … of FimH bound to α-d-mannose, and mannose
derivatives, called mannosides (37–39), were used to rationally design biphenyl FimH inhibitors …

… Escherichia coli ST131 causes acute urinary tract infection in female C3H/HeN mice. Scatter
plots of E. coli EC958 titers (colony-forming units [CFU]/organ) in bladders (A) and kidneys (…

… (39, 41, 42) Nonspecific interactions to the various mannose receptors by FimH inhibitors
would have a profound impact on these processes. We therefore determined the affinity of …

… in binding affinity of FimH antagonists with FimH FL and FimH LD , respectively, we studied
the binding thermodynamics of the FimH antagonists 1 and 3p for both FimH proteins by …

… We hypothesized that the fitness advantage of expressing FimH::A62/V163 over FimH::S62/A163
throughout infection was due to differences in the ability to bind mannosylated epitopes …

… We demonstrate that α-d-mannose based inhibitors of FimH not only block bacterial
adhesion on uroepithelial cells but also antagonize invasion and biofilm formation. Heptyl α-d-…

… of urinary tract infections conducted with FimH antagonists. … with antibodies directed against
FimH, protected animals from … the inhibition of the initial host-pathogen interaction with FimH …

… effective FimH inhibitors. During this period, a variety of synthetic mannosides and naturally
occurring oligosaccharides isolates were further identified as inhibitors of the FimH lectin. …

… This consequently led to a new structural series of FimH inhibitors disclosed in a new
application[Citation47], with the most potent heterocyclic derivatives being thiophene urea …

… the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic
… heterogeneities of different FimH variants, several FimH inhibitors have been developed …