[HTML][HTML] Drug resistance

R Laxminarayan, Z Bhutta, A Duse, P Jenkins… - 2011 - europepmc.org
… with a resistant infection are less likely to have access to or be able to afford expensive
second-line treatments, which typically have more complex regimens than first-line drugs. …

Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa

TS Boender, CM Kityo, RS Boerma… - Journal of …, 2016 - academic.oup.com
resistance and predicted drug susceptibility to NNRTIs and NRTIs after continued virological
failure on first-line … to adult care, we compared drug resistance rates and patterns in adults …

HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study

AS Hassan, HM Nabwera, SM Mwaringa… - AIDS research and …, 2014 - Springer
… , targeted HIV drug resistance testing for … drug resistance of 11% in patients on ART for
12–23 months, 15% at 24–36 months and 21% at >36 months [16]. The most common resistance

Treatment of isoniazid-resistant tuberculosis with first-line drugs: a systematic review and meta-analysis

M Gegia, N Winters, A Benedetti… - The Lancet Infectious …, 2017 - thelancet.com
… -resistant tuberculosis and 19 012 patients with drug-sensitive disease. The pooled rates of
failure or relapse, or both, and acquired drug resistance with all drug … -resistant tuberculosis …

Accumulation of HIV drug resistance mutations in patients failing first-line antiretroviral treatment in South Africa

KCE Sigaloff, T Ramatsebe, R Viana… - AIDS research and …, 2012 - liebertpub.com
… In conclusion, the degree and pattern of HIV drug resistance detected after prolonged
virological failure of first-line ART are likely to negatively impact future regimes containing NRTI …

The global impact of drug resistance

DH Howard, RD Scott, R Packard… - Clinical Infectious …, 2003 - academic.oup.com
… If the prevalence of resistance is high, then physicians will begin using secondline drugs
as … Chloroquine was the main antimalarial agent used for firstline treatment of malaria for …

Multidrug-resistant tuberculosis treatment outcomes in relation to treatment and initial versus acquired second-line drug resistance

JP Cegielski, E Kurbatova… - Clinical Infectious …, 2016 - academic.oup.com
… , laboratory, and program variables against drug resistance patterns, treatment, and outcomes…
We used multiple logistic regressions to compare outcomes by drug resistance pattern and …

Risk factors for multi-drug resistant pathogens and failure of empiric first-line therapy in acute cholangitis

PA Reuken, D Torres, M Baier, B Löffler, C Lübbert… - PloS one, 2017 - journals.plos.org
… increasing prevalence of multi-drug resistant (MDR) bacteria, … microorganisms and therapeutic
failure, we analyzed the first … Multi-drug resistant (MDR) bacteria were isolated from the …

… of MGIT 960-based antimicrobial testing and determination of critical concentrations of first-and second-line antimicrobial drugs with drug-resistant clinical strains of …

A Krüüner, MD Yates… - Journal of clinical …, 2006 - Am Soc Microbiol
… for first-line drugs with a methodology (the resistance ratio method [RRM]) that had been
used in clinical trials, relating drug … (MPA) methodologies for second-line drug testing; and (iii) …

Adverse drug reactions associated with first-line anti-tuberculosis drug regimens

F Marra, CA Marra, N Bruchet… - … of Tuberculosis and …, 2007 - ingentaconnect.com
… of drug resistance. In summary, we found that the currently available first-line anti-tuberculosis
drugs … As many of these drugs were developed several decades ago, little research has …