… The majority of drug resistance in clinical MTB strains is attributed to chromosomal mutations…
resistance leading to drug resistance include drug target alteration, overexpression of drug …

… This helped influence a decision to move to eflornithine as first line treatment at the Omugo
Treatment Center in Northern Uganda. Interestingly, when parasite genotypes were tested …

… , and may be due to inadequate drug exposure or alterations in the cancer … drug resistance,
focussing on work in our institution related to the treatment of ovarian cancer and resistance …

… phenotype, as well as in vivo as a therapy for mice infected with multi-drug resistant
strains of Mtb, or for human subjects infected with extensively drug resistant (XDR) Mtb. The …

… pyrimethamine (SP) as first line drug for the treatment of … first line drug to SP. In 1985,
eventually SP was replaced by mefloquine. The rapid development of resistance to this new drug …

… drug resistance tests in settings where drug resistance is … resistant to second-line anti-TB
drugs differs from what has been reported previously for resistance to first-line anti-TB drugs in …

… In the current review we ask: Are drug resistance mechanisms that emerge following … lead
to the same drug resistance modality? This question portends critical drug treatment decisions (…

… Resistance to antituberculosis drugs was first described soon after the introduction of … ), the
prevalence of drug resistance to any of the standard first-line tuberculosis drugs ranged from …

… , it is important to distinguish drug resistance — the heritable ability of an organism to resist
the effects of an antibiotic to which its parent was susceptible — from drug tolerance and …

… such extensive drug resistance as to be nearly untreatable with currently available drugs,
according to international guidelines. We provide data on second-line–drug resistance for the …