Erlotinib as single agent first line treatment in locally advanced or metastatic activating EGFR mutation-positive lung adenocarcinoma (CEETAC): an open-label, non …

Z Markóczy, V Sárosi, I Kudaba, G Gálffy, ÜY Turay… - BMC cancer, 2018 - Springer
… efficacy and safety of first line erlotinib monotherapy in Caucasian patients with locally
advanced or metastatic lung adenocarcinoma carrying activating EGFR mutations based on the …

[HTML][HTML] Meta-analysis of first-line therapies in advanced non–small-cell lung cancer harboring EGFR-activating mutations

B Haaland, P San Tan, G de Castro Jr… - Journal of Thoracic …, 2014 - Elsevier
… , erlotinib, afatinib, and chemotherapy as first-line therapies for patients with advanced NSCLC
harboring EGFR-activating mutations in … population associated with EGFR mutations, but …

Erlotinib in the first-line treatment of non-small-cell lung cancer

M D'Arcangelo, F Cappuzzo - Expert review of anticancer therapy, 2013 - Taylor & Francis
activating mutations of the EGFR gene. The aim of this article is to analyze available data of
EGFR-TKIs in the front-line … of erlotinib in patients harboring an activating EGFR mutation, …

Afatinib, erlotinib and gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: a review

J Köhler, M Schuler - Onkologie, 2013 - karger.com
… highest in patients with tumors harboring the activating EGFR gene mutations [36, 43–46]
(… first-line erlotinib or gefitinib with cytotoxic chemotherapy in patients with proven EGFR-mutant

Prospective evaluation of first-line erlotinib in advanced non-small cell lung cancer (NSCLC) carrying an activating EGFR mutation: A multicenter academic phase II …

J De Grève, J Van Meerbeeck, JF Vansteenkiste… - PLoS …, 2016 - journals.plos.org
… such mutations are more prevalent. We report on the long-term results of first-line treatment
with erlotinib … adenocarcinoma of the lung that have a somatic EGFR mutation in their tumor. …

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a …

C Zhou, YL Wu, G Chen, J Feng, XQ Liu… - The lancet …, 2011 - thelancet.com
first phase 3 study to show that patients with EGFR mutation-positive NSCLC who receive
erlotinib … tumours have confirmed EGFR activating mutations should receive erlotinib as first-…

First-line treatment of EGFR-mutant non-small-cell lung cancer: the role of erlotinib and other tyrosine kinase inhibitors

KSH Nguyen, JW Neal - Biologics: Targets and Therapy, 2012 - Taylor & Francis
… group similarly identified EGFR mutations that were associated with sensitivity to gefitinib
and erlotinib. Citation15 These EGFR mutations activate the EGFR signaling pathway that …

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… (NSCLC) with activating EGFR mutations. We aimed to … of erlotinib compared with
standard chemotherapy for first-line treatment of European patients with advanced EGFR-mutation

[HTML][HTML] First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III …

YL Wu, C Zhou, CK Liam, G Wu, X Liu, Z Zhong, S Lu… - Annals of oncology, 2015 - Elsevier
… , and activating mutations are often seen in NSCLC [2]. EGFR mutations occur more …
However, studies have shown that EGFR tyrosine kinase inhibitors (TKIs) including erlotinib

… of efficacy and safety of erlotinib as first-line TKI treatment in EGFR mutation-positive advanced non-small cell lung cancer: Results from the EGFR-2013-CPHG study

T Payen, J Trédaniel, L Moreau, S Larivé… - … Medicine and Research, 2021 - Elsevier
… -small cell lung cancer (NSCLC) patients with EGFR-activating mutations. Using a cohort
of unselected patients treated with erlotinib, we sought to further describe patient and tumour …