Purpose This phase III study compared the safety and efficacy of the following three different
irinotecan-containing regimens in the first-line treatment of metastatic colorectal cancer: …

… studies assessing ETV and TDF as first-line therapies for CHB have confirmed the results
obtained in clinical trials, … rates comparable to those in registration studies and with low rates of …

… has shown potential anticancer effects in preclinical and clinical studies. We aimed to establish
whether bisphosphonates can affect clinical outcomes in patients with multiple myeloma. …

… trials have shown this strategy to be … the treatment pyramid for patients with recent-onset
rheumatoid arthritis. In this report, we describe the first-year results of a randomized clinical trial …

… Our analysis showed that improvements in PFS, TTP, and RR were all strongly associated
with an improvement in OS in randomized control trials of first-line chemotherapy for MCRC. …

… a first-line phase III randomized clinical trial on metastatic colorectal cancer (mCRC) aimed
at evaluating the effectiveness of adding bevacizumab (B) to standard first-line chemotherapy …

… We performed a randomized controlled trial comparing intravenous pulse therapy with …
other treatment such as surgery or radiotherapy. To assess disease activity we used the Clinical …

… As a consequence of the lower representation of elderly patients in clinical trials… clinical
trials in community settings. Combined analyses of data accrued from prospective clinical studies …

… controlled trials (RCTs) that were appropriate for inclusion in the metaanalysis, we conducted
a systematic search of the PubMed and the Cochrane Central Register of Controlled Trials. …

… with carboplatin and pemetrexed as first-line therapy provides better survival … as first-line
therapy for EGFR-mutated NSCLC.20 The results in another prospective single arm clinical trial …