… the first randomised controlled trial that investigates the effectiveness of first-line IFX in
therapy-naïve … with moderate-to-severe Crohn’s disease would benefit from first-line IFX treatment. …

… The most reliable information will come from controlled clinical trials of … studies, each group
of the controlled clinical trial was classified according to whether or not the primary treatment …

… clinical trial that evaluated the efficacy and safety of single agent of capecitabine was the
maintenance therapy after first-line … and comparable with that of other similar studies [10., 11., 12…

… In this multicentre randomised controlled trial we compared initial treatment of OAG or
ocular hypertension using selective laser trabeculoplasty followed by medication, if required, …

… more objective appraisal of treatment benefit than the consideration of individual studies.17, …
to standard first-line chemotherapy in the CRYSTAL and OPUS clinical trials.9, 10 …

Background The irreversible ErbB family blocker afatinib and the reversible EGFR tyrosine
kinase inhibitor gefitinib are approved for first-line treatment of EGFR mutation-positive non-…

… ”, “first-line”, and “chemotherapy-naive”. Only randomized controlled trials that fulfilled the
criteria … The relevant reviews and meta-analyses regarding the role of the first-line treatment for …

… intraoperatively as first-line hemostatic therapy, and the first placebo-controlled study of …
randomized clinical studies of fibrinogen concentrate have been performed.14,16In the first one, …

… II trials 22,24 reported that sorafenib plus erlotinib had promising activity as first-line therapy
… erlotinib alone as second- or third-line treatment showed that, although PFS and ORRs were …

… We conducted a meta-analysis of first-line clinical trials available up to October 2016, which
assessed the relevance of PTL in patients with metastatic colorectal cancer (mCRC). Right- …