… of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small …

L Wood, M Palmer, J Hewitt, R Urtasun, E Bruera… - British journal of …, 1998 - nature.com
… This is the first randomized, placebo-controlled trial using MA … use at the time of first-line
cytotoxic therapy results in a survival … There have been other randomized clinical trials studying …

… chemotherapy as first-line treatment for chemotherapy-naive patients with advanced non-small cell lung cancer: a meta-analysis of randomised controlled trials

F Wang, LD Wang, B Li, ZX Sheng - Clinical Oncology, 2012 - Elsevier
… In conclusion, first-line treatment with gefitinib conferred prolonged progression-free
survival than treatment with systemic chemotherapy in a molecularly or histologically defined …

Patient reported outcomes of a randomized, placebo-controlled trial of bevacizumab in the front-line treatment of ovarian cancer: a Gynecologic Oncology Group Study

BJ Monk, HQ Huang, RA Burger, RS Mannel… - Gynecologic …, 2013 - Elsevier
… in a randomized, placebo-controlled phase III trial concluding that the addition of concurrent
… progression-free survival in front-line treatment of advanced ovarian cancer compared to …

… and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials

F Brigo, NL Bragazzi, S Bacigaluppi, R Nardone… - Epilepsy & Behavior, 2016 - Elsevier
… , EMBASE, ClinicalTrials.gov ) to identify randomized controlled trials (RCTs) comparing
IV LZP versus IV DZP used as first-line treatment for convulsive SE (generalized or focal). …

Is metformin still the most efficacious firstline oral hypoglycaemic drug in treating type 2 diabetes? A network meta‐analysis of randomized controlled trials

Y Jia, Y Lao, H Zhu, N Li, SW Leung - Obesity Reviews, 2019 - Wiley Online Library
… insufficient studies to form well-connected networks. Our findings confirmed the efficacy of
metformin as the first-line treatment for T2DM in consistency with the current clinical guidelines …

… , controlled trial investigating short-term health-related quality of life with doxorubicin and paclitaxel versus doxorubicin and cyclophosphamide as first-line …

A Bottomley, L Biganzoli, T Cufer… - Journal of clinical …, 2004 - ascopubs.org
clinical trials in metastatic breast cancer have been published without HRQOL data. Unfortunately,
such studies do not weigh the benefits of treatment … can impair clinical decision making…

Updated European Association of Urology Guidelines: recommendations for the treatment of first-line metastatic clear cell renal cancer

T Powles, L Albiges, M Staehler, K Bensalah… - European urology, 2018 - Elsevier
… III clinical trial Checkmate-214 showed a survival superiority for the combination of ipilimumab
and nivolumab when compared with the previous standard of care in first-line metastatic/…

Tislelizumab vs sorafenib as first-line treatment for unresectable hepatocellular carcinoma: a phase 3 randomized clinical trial

S Qin, M Kudo, T Meyer, Y Bai, Y Guo, Z Meng… - JAMA …, 2023 - jamanetwork.com
… derived from randomized controlled trials. Though our … compared to similar clinical trials,
notably the IMbrave 150 trial (3… , a factor typically excluded from clinical trial eligibility criteria. As …

Comparative effectiveness of multiple different first-line treatment regimens for Helicobacter pylori infection: a network meta-analysis

T Rokkas, JP Gisbert, P Malfertheiner, Y Niv… - Gastroenterology, 2021 - Elsevier
… Data extracted from eligible randomized controlled trials were entered into a … first-line
regimens and to explore their effectiveness rank order. The ranking probability for each regimen

… controlled trial of single-agent paclitaxel versus cyclophosphamide, doxorubicin, and cisplatin in patients with recurrent ovarian cancer who responded to first-line …

MG Cantu, A Buda, G Parma, R Rossi… - Journal of clinical …, 2002 - ascopubs.org
… To our knowledge, this is the first randomized trial aimed at comparing paclitaxel therapy
and platinum-based therapy in patients relapsing after 12 months of complete remission. …