… of trastuzumab as first-line treatment of patients with … efficacy and preserves the QOL. In
conclusion, single-agent trastuzumab is an active and well tolerated option for first-line treatment …

… recommended a first-line antiretroviral therapy regimen that … the preferred option for first-line
therapy, although a ritonavir-… -based regimen can also be used in a first-line regimen in …

Objective To compare the efficacy and safety of first line treatments for patients with advanced
epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC). …

… the high efficacy of propranolol as first-line treatment for … the good overall tolerance of
this therapy in young infants. … accurately investigate the efficacy and safety of propranolol …

… the efficacy and safety of first-line … NMA of first-line chemotherapy regimens is available yet.
Therefore, we conducted a systematic review to investigate the efficacy and safety of first-line …

… S-1 is first-line therapy for advanced … the efficacy and toxicity of S-1-based therapy compared
with 5-fluorouracil (5-FU)/capecitabine-based therapy and S-1-based combination therapy …

… We report exploratory sub-analyses of safety and efficacy in elderly patients, defined as ⩾65
years old, in AVastin And DOcetaxel (AVADO) receiving first-line bevacizumab plus …

Purpose This randomized, multicenter trial compared first-line trastuzumab plus docetaxel
versus docetaxel alone in patients with human epidermal growth factor receptor 2 (HER2) –…

… Without head-to-head clinical trials of these different treatment options, we are reliant … efficacy,
safety, health-related quality of life, and patient-reported outcomes for first-line treatment of …

… and toxicity and preserving future treatment options. We aimed to assess the efficacy and
safety of dual-therapy versus triple therapy as first-line treatment or in treatment simplification. …