… first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… compared with chemotherapy when given as first-line treatment for Asian patients with non-…
for first-line treatment of European patients with advanced EGFR-mutation positive NSCLC. …

Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial

JM Liou, CC Chen, MJ Chen, CC Chen, CY Chang… - The Lancet, 2013 - thelancet.com
treatment allocation. Our primary outcome was the eradication rate in first-line treatment by
intention-to-treat … sequential treatment as the standard first-line treatment for H pylori infection. …

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3 …

A Sezer, S Kilickap, M Gümüş, I Bondarenko… - The Lancet, 2021 - thelancet.com
Background We aimed to examine cemiplimab, a programmed cell death 1 inhibitor, in the
first-line treatment of advanced non-small-cell lung cancer with programmed cell death ligand …

Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial

PA Jänne, SHI Ou, DW Kim, GR Oxnard… - The lancet …, 2014 - thelancet.com
… In this open-label, multicentre, phase 2 trial, we enrolled treatment-naive patients with
advanced lung cancer who had clinical (never-smokers [<100 cigarettes per lifetime] or former …

… as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised …

C Zhou, YL Wu, G Chen, J Feng, XQ Liu… - The lancet …, 2011 - thelancet.com
… (TKIs) have greater first-line efficacy than does chemotherapy in EGFR mutation-positive
NSCLC. We recommend that EGFR TKIs be regarded as the first-line treatment of choice for this …

[HTML][HTML] Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, phase II safety study

J Bruix, WY Tak, A Gasbarrini, A Santoro… - European journal of …, 2013 - Elsevier
… an uncontrolled, open-label, phase II study of regorafenib as second-line therapy in patients
with … cycles of 3 weeks on treatment followed by 1 week off treatment as the recommended …

First-line treatment with infliximab versus conventional treatment in children with newly diagnosed moderate-to-severe Crohn's disease: an open-label multicentre …

MME Jongsma, MA Aardoom, MA Cozijnsen… - Gut, 2022 - gut.bmj.com
… We aimed to investigate whether starting first-line IFX (FL-IFX) is more effective to achieve
and maintain remission than conventional treatment. Design In this multicentre open-label

… as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 2014-01 TPExtreme): a multicentre, open-label …

J Guigay, A Aupérin, J Fayette, E Saada-Bouzid… - The Lancet …, 2021 - thelancet.com
regimen could provide an alternative to standard of care with the EXTREME regimen in the
first-line treatment … who might not be good candidates for up-front pembrolizumab treatment. …

… non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen (IPSOS): a phase 3, global, multicentre, open-label, randomised controlled study

SM Lee, C Schulz, K Prabhash, D Kowalski… - The Lancet, 2023 - thelancet.com
First-line treatment with atezolizumab monotherapy was associated with improved overall
… These data support atezolizumab monotherapy as a potential first-line treatment option for …

… bevacizumab in combination with FOLFOX or FOLFIRI as first-line treatment for metastatic colorectal cancer: a multicentre, open-label, randomised controlled trial

A Romera, S Peredpaya, Y Shparyk… - The Lancet …, 2018 - thelancet.com
… The study was open label, so neither investigators nor participants were masked to
treatment assignment. However, drug concentration analysis for the primary pharmacokinetic …